Abstract
Optical sectioning of biological specimens provides detailed volumetric information regarding their internal structure. To provide a complementary approach to existing three-dimensional (3D) microscopy modalities, we have recently demonstrated lensfree optical tomography that offers high-throughput imaging within a compact and simple platform. In this approach, in-line holograms of objects at different angles of partially coherent illumination are recorded using a digital sensor-array, which enables computing pixel super-resolved tomographic images of the specimen. This imaging modality, which forms the focus of this review, offers micrometer-scale 3D resolution over large imaging volumes of, for example, , and can be assembled in light weight and compact architectures. Therefore, lensfree optical tomography might be particularly useful for lab-on-a-chip applications as well as for microscopy needs in resource-limited settings.
©2011 Optical Society of America
Full Article | PDF ArticleMore Like This
Onur Mudanyali, Waheb Bishara, and Aydogan Ozcan
Opt. Express 19(18) 17378-17389 (2011)
Alon Greenbaum and Aydogan Ozcan
Opt. Express 20(3) 3129-3143 (2012)
Waheb Bishara, Ting-Wei Su, Ahmet F. Coskun, and Aydogan Ozcan
Opt. Express 18(11) 11181-11191 (2010)