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Probability density function of the electric field in diffuse correlation spectroscopy of human bone in vivo

Tiziano Binzoni, Bruno Sanguinetti, Dimitri Van de Ville, Hugo Zbinden, and Fabrizio Martelli

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Abstract

Diffuse correlation spectroscopy (DCS) is the technique of choice for non-invasive assessments of human bone blood flow. However, DCS classical algorithms are based on the fundamental assumption that the electric field of the light reaching the DCS photodetector is a zero-mean complex Gaussian variable. The non-validity of this hypothesis might produce inaccurate blood flow estimations. It is shown that for the human tibia, the “Gaussian hypothesis” holds for interoptode distances ≥20  mm. This lower boundary seems to depend on the type of investigated tissue.

© 2016 Optical Society of America

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