Abstract

The detection and identification of biologically important molecules has critical importance in several fields such as medicine, biotechnology, and pharmacology. Surface-enhanced Raman scattering (SERS) is a powerful emerging vibrational spectroscopic technique that allows not only for the characterization, but also for the identification and detection of biomacromolecules in a very short time. In this review, efforts to utilize SERS for label-free protein detection and identification is summarized after a short introduction of proteins and the technique.

Label free hepatitis B detection based on serum derivative surface enhanced Raman spectroscopy combined with multivariate analysis

Yudong Lu, Yisheng Lin, Zuci Zheng, Xiaoqiong Tang, Jinyong Lin, Xiujie Liu, Mengmeng Liu, Guannan Chen, Sufang Qiu, Ting Zhou, Yao Lin, and Shangyuan Feng
Biomed. Opt. Express 9(10) 4755-4766 (2018)

Lamellar hafnium ditelluride as an ultrasensitive surface-enhanced Raman scattering platform for label-free detection of uric acid

Yang Li, Haolin Chen, Yanxian Guo, Kangkang Wang, Yue Zhang, Peilin Lan, Jinhao Guo, Wen Zhang, Huiqing Zhong, Zhouyi Guo, Zhengfei Zhuang, and Zhiming Liu
Photon. Res. 9(6) 1039-1047 (2021)

Leukemia cells detection based on electroporation assisted surface-enhanced Raman scattering

Yun Yu, Juqiang Lin, Duo Lin, Shangyuan Feng, Weiwei Chen, Zufang Huang, Hao Huang, and Rong Chen
Biomed. Opt. Express 8(9) 4108-4121 (2017)

Label-free surface-enhanced Raman spectroscopy for detection of colorectal cancer and precursor lesions using blood plasma

Shangyuan Feng, Wenbo Wang, Isabella T. Tai, Guannan Chen, Rong Chen, and Haishan Zeng
Biomed. Opt. Express 6(9) 3494-3502 (2015)

RETRACTED: Optimal DNA structure of reverse-hairpin beacons for label-free and positive surface enhanced Raman scattering assays

Jisun Ki, Jinyoung Kim, SEeungmin Han, Eunji Jang, Taeksu Lee, Jung-Sub Wi, Tae Geol Lee, Woonsung Na, Daesub Song, and Seungjoo Haam
Opt. Mater. Express 7(7) 2352-2360 (2017)