Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group
  • Medical Laser Applications and Laser-Tissue Interactions VII
  • SPIE Proceedings (Optica Publishing Group, 2015),
  • paper 95420F

Healing process study in murine skin superficial wounds treated with the blue LED photocoagulator “EMOLED”

Not Accessible

Your library or personal account may give you access


A faster healing process was observed in superficial skin wounds after irradiation with the EMOLED photocoagulator. The instrument consists of a compact handheld photocoagulation device, useful for inducing coagulation in superficial abrasions. In this work we present the results of an in vivo study, in a murine model. Two superficial wounds were produced on the back of 12 mice: one area was left untreated, the other one was treated with EMOLED. Healthy skin was used as a control. The animals were sacrificed 3 hours, 12 hours, 1 day, 6 day after treatment. The treatment effects on back skin was monitored by visual observations, histopathological analysis, immuno-histochemical analysis, and nonlinear microscopic imaging performed at each follow up time, finding no adverse reactions and no thermal damage in both treated areas and surrounding tissues. In addition, a faster healing process, a reduced inflammatory response, a higher collagen content, and a better-recovered skin morphology was evidenced in the treated tissue with respect to the untreated tissue. These morphological features were characterized by means of immuno-histochemical analysis, aimed at imaging fibroblasts and myofibroblasts, and by SHG microscopy, aimed at characterizing collagen organization, demonstrating a fully recovered aspect of dermis as well as a faster neocollagenesis in the treated regions. This study demonstrates that the selective photothermal effect we used for inducing immediate coagulation in superficial wounds is associated to a minimal inflammatory response, which provides reduced recovery times and improved healing process.

© 2015 SPIE

PDF Article
More Like This
In vivo wound healing modulation after irradiation with a blue LED photocoagulator

Francesca Rossi, Riccardo Cicchi, Giada Magni, Francesca Tatini, Stefano Bacci, Gaia Paroli, Domenico Alfieri, Cristina Tripodi, Gaetano De Siena, Francesco S. Pavone, and Roberto Pini
1041706 European Conference on Biomedical Optics (ECBO) 2017

Improved Wound Healing in Blue LED Treated Superficial Abrasions

Francesca Rossi, Francesca Tatini, Roberto Pini, Stefano Bacci, Gaetano De Siena, Riccardo Cicchi, Francesco Pavone, and Domenico Alfieri
88030S European Conference on Biomedical Optics (ECBO) 2013

Quantitative Multimodal 3D Characterization of Cellular Dynamics in Wounded Skin

Joanne Li, Andrew J. Bower, Eric J. Chaney, Marina Marjanovic, and Stephen A. Boppart
BoTu1A.4 Bio-Optics: Design and Application (BODA) 2017


You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
Login to access Optica Member Subscription

Select as filters

Select Topics Cancel
© Copyright 2023 | Optica Publishing Group. All Rights Reserved