Abstract

Second-harmonic generation microscopy can provide estimation of some local molecule distribution properties. However, in order not to get erroneous conclusions, it is important to detect measurements with insufficient precision. Such a detection technique is developed considering an approximation of the ultimate precision provided by the Cramer–Rao bound. This method is characterized and a simple approximation of its detection and false alarm probabilities is developed.

© 2016 Optical Society of America

Precision of polarization-resolved second harmonic generation microscopy limited by photon noise for samples with cylindrical symmetry

Valentine Wasik, Philippe Réfrégier, Muriel Roche, and Sophie Brasselet
J. Opt. Soc. Am. A 32(8) 1437-1445 (2015)

Precision of proportion estimation with binary compressed Raman spectrum

Philippe Réfrégier, Camille Scotté, Hilton B. de Aguiar, Hervé Rigneault, and Frédéric Galland
J. Opt. Soc. Am. A 35(1) 125-134 (2018)

Fisher information theory for parameter estimation in single molecule microscopy: tutorial

Jerry Chao, E. Sally Ward, and Raimund J. Ober
J. Opt. Soc. Am. A 33(7) B36-B57 (2016)

Precision analysis in polarization-resolved second harmonic generation microscopy

Philippe Réfrégier, Muriel Roche, and Sophie Brasselet
Opt. Lett. 36(11) 2149-2151 (2011)

Polarization-resolved second harmonic generation microscopy with a four-channel Stokes-polarimeter

Nirmal Mazumder, Jianjun Qiu, Matthew R. Foreman, Carlos Macías Romero, Chih-Wei Hu, Han-Ruei Tsai, Peter Török, and Fu-Jen Kao
Opt. Express 20(13) 14090-14099 (2012)