Abstract
We designed a rapid functional imager for the parallel recording of localized intrinsic optical signals (IOSs). This imager used a microlens array (MLA)-based illuminator to deliver visible stimulus light and near-infrared (NIR) recording light simultaneously. The parfocal configuration of the stimulus and recording light illumination enabled confocal recording of the stimulus-evoked IOSs. Because the MLA stimulation/recording spots were widely separated on the retina, and only the photoreceptors within the MLA stimulation/recording spots were stimulated, the potential IOS cross talk effect among neighboring retinal areas was minimized. Our experiments revealed robust IOS activities tightly correlated with localized retinal responses.
© 2010 Optical Society of America
Full Article | PDF ArticleMore Like This
Yi-Chao Li, Christianne Strang, Franklin R. Amthor, Lei Liu, Yang-Guo Li, Qiu-Xiang Zhang, Kent Keyser, and Xin-Cheng Yao
Opt. Lett. 35(11) 1810-1812 (2010)
Yang-Guo Li, Qiu-Xiang Zhang, Lei Liu, Franklin R. Amthor, and Xin-Cheng Yao
Opt. Express 18(7) 7210-7218 (2010)
Yang-Guo Li, Lei Liu, Franklin Amthor, and Xin-Cheng Yao
Opt. Lett. 35(3) 426-428 (2010)