Abstract
A nonparametric deconvolution algorithm for recovering the photon time-of-flight distribution (TOFD) from time-resolved (TR) measurements is described. The algorithm combines wavelet denoising and a two-stage deconvolution method based on generalized singular value decomposition and Tikhonov regularization. The efficacy of the algorithm was tested on simulated and experimental TR data and the results show that it can recover the photon TOFD with high fidelity. Combined with the microscopic Beer–Lambert law, the algorithm enables accurate quantification of absorption changes from arbitrary time-of-flight windows, thereby optimizing the depth sensitivity provided by TR measurements.
©2012 Optical Society of America
Full Article | PDF ArticleMore Like This
Mamadou Diop and Keith St. Lawrence
Biomed. Opt. Express 4(3) 447-459 (2013)
Adam Liebert, Heidrun Wabnitz, Jens Steinbrink, Hellmuth Obrig, Michael Möller, Rainer Macdonald, Arno Villringer, and Herbert Rinneberg
Appl. Opt. 43(15) 3037-3047 (2004)
Jonathan T. Elliott, Daniel Milej, Anna Gerega, Wojciech Weigl, Mamadou Diop, Laura B. Morrison, Ting-Yim Lee, Adam Liebert, and Keith St. Lawrence
Biomed. Opt. Express 4(2) 206-218 (2013)