Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Quantitative Mueller matrix fluorescence spectroscopy for precancer detection

Not Accessible

Your library or personal account may give you access

Abstract

Quantitative fluorescence spectroscopic Mueller matrix measurements from the connective tissue regions of human cervical tissue reveal intriguing fluorescence diattenuation and polarizance effects. Interestingly, the estimated fluorescence linear diattenuation and polarizance parameters were considerably reduced in the precancerous tissues as compared to the normal ones. These polarimetry effects of the autofluorescence were found to originate from anisotropically organized collagen molecular structures present in the connective tissues. Consequently, the reduction of the magnitude of these polarimetric parameters at higher grades of precancer was attributed to the loss of anisotropic organization of collagen, which was also confirmed by control experiments. These results indicate that fluorescence spectral diattenuation and polarizance parameters may serve as potentially useful diagnostic metrics.

© 2014 Optical Society of America

Full Article  |  PDF Article
More Like This
Quantitative fluorescence and elastic scattering tissue polarimetry using an Eigenvalue calibrated spectroscopic Mueller matrix system

Jalpa Soni, Harsh Purwar, Harshit Lakhotia, Shubham Chandel, Chitram Banerjee, Uday Kumar, and Nirmalya Ghosh
Opt. Express 21(13) 15475-15489 (2013)

Different orders of scattering through time-resolved Mueller matrix imaging estimates of pre-malignancy in human cervical tissues

Mohammad Zaffar, Gyana Ranjan Sahoo, and Asima Pradhan
Appl. Opt. 59(14) 4286-4295 (2020)

Quantitative polarimetry Mueller matrix decomposition approach for diagnosing melanoma and non-melanoma human skin cancer

Armaghan Vahidnia, Khosro Madanipour, Robabeh Abedini, Reza Karimi, Joseph Sanderson, Zahra Zare, and Parviz Parvin
OSA Continuum 4(11) 2862-2874 (2021)

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (3)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved