Abstract
Micro-optical coherence tomography (μOCT) is an advanced imaging technique that acquires a three-dimensional microstructure of biological samples with a high spatial resolution, up to 1 μm, by using a broadband light source and a high numerical aperture (NA) lens. As high NA produces a short depth of focus (DOF), extending the DOF is necessary to obtain a reasonable imaging depth. However, due to the complexity of optics and the limited space, it has been challenging to fabricate endoscopic μOCT, which is essential for clinical translation. Here, we report an endoscopic μOCT probe with an extended DOF by using a binary phase spatial filter. The imaging results from latex beads demonstrated that the μOCT probe achieved an axial resolution of 2.49 μm and a lateral resolution of 2.59 μm with a DOF extended by a factor of 2. The feasibility of clinical use was demonstrated by ex vivo imaging of the rabbit iliac artery.
© 2017 Optical Society of America
Full Article | PDF ArticleMore Like This
Wenchao Liao, Tianyuan Chen, Chengming Wang, Wenxin Zhang, Zhangkai Peng, Xiao Zhang, Shengnan Ai, Deyong Fu, Tieying Zhou, and Ping Xue
Opt. Lett. 42(20) 4040-4043 (2017)
Dongyao Cui, Kengyeh K. Chu, Biwei Yin, Timothy N. Ford, Chulho Hyun, Hui Min Leung, Joseph A. Gardecki, George M. Solomon, Susan E. Birket, Linbo Liu, Steven M. Rowe, and Guillermo J. Tearney
Opt. Lett. 42(4) 867-870 (2017)
Jinhan Li, Yuemei Luo, Xianghong Wang, Nanshuo Wang, En Bo, Si Chen, Shufen Chen, Shi Chen, Meng-Tsan Tsai, and Linbo Liu
Appl. Opt. 57(21) 6040-6046 (2018)