Abstract

We have recorded time-resolved transillumination images of solid phantoms with objects embedded that differ in their scattering and absorption coefficients from those of the bulk material, simulating a compressed human breast with a tumor inside. Employing time-correlated single photon counting at rates of up to 1 MHz, we recorded distributions of times of flight of photons at 1369 scan positions within 2.5 min. Several quantities, such as fractional transmittance, first moments, Fourier amplitudes, phase shifts, and frequency-dependent effective transport scattering and absorption coefficients, have been derived from experimental data to form two-dimensional images. By recording such images at a selected total number of photons detected, we have determined the contrast and effective signal-to-noise ratio in each case.

© 1997 Optical Society of America

Time-resolved optical imaging of a solid tissue-equivalent phantom

Jeremy C. Hebden, David J. Hall, Michael Firbank, and David T. Delpy
Appl. Opt. 34(34) 8038-8047 (1995)

Development of a time-domain optical mammograph and first in vivo applications

Dirk Grosenick, Heidrun Wabnitz, Herbert H. Rinneberg, K. Thomas Moesta, and Peter M. Schlag
Appl. Opt. 38(13) 2927-2943 (1999)

Time-resolved imaging on a realistic tissue phantom: μs′ and μa images versus time-integrated images

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini
Appl. Opt. 35(22) 4533-4540 (1996)

Time-domain optical mammography: initial clinical results on detection and characterization of breast tumors

Dirk Grosenick, K. Thomas Moesta, Heidrun Wabnitz, Jörg Mucke, Christian Stroszczynski, Rainer Macdonald, Peter M. Schlag, and Herbert Rinneberg
Appl. Opt. 42(16) 3170-3186 (2003)

Three-dimensional time-resolved optical mammography of the uncompressed breast

Louise C. Enfield, Adam P. Gibson, Nicholas L. Everdell, David T. Delpy, Martin Schweiger, Simon R. Arridge, Caroline Richardson, Mohammad Keshtgar, Michael Douek, and Jeremy C. Hebden
Appl. Opt. 46(17) 3628-3638 (2007)