Abstract

A computer-microscope system is described for use in capturing accurate, quantitative schematic (map) information from anatomical tissue sections. The system provides a rapid and convenient environment for acquisition and analysis of complex structures spread over large 3-D regions of the tissue. As a consequence of the complexity and subtlety of tissue analysis, most of the data acquisition functions of the system involve tight coupling between the hardware and the microscopist to preserve access to human judgment and intelligence. The instrument profoundly affects the ease and accuracy of neurobiological data analysis, making it practical to address previously inaccessible problems. Examples of data analyzed using the system are shown.

© 1987 Optical Society of America

Computer-aided morphometric data collection, mapping, and analysis for neuropathologists

Donald G. Lloyd, Harry L. Loats, Donald L. Price, and Linda C. Cork
Appl. Opt. 26(16) 3390-3397 (1987)

Computer-aided microscopy in medicine: introduction to the 15 August 1987 issue of Applied Optics

Norman J. Pressman
Appl. Opt. 26(16) 3199-3209 (1987)

A PC-based system for the objective analysis of histologic specimens through quantitative contextual karyometry

Harvey E. Dytch, Marluce Bibbo, Peter H. Bartels, James H. Puls, and George L. Wied
Appl. Opt. 26(16) 3270-3279 (1987)

Optical memory disks in image data-base management for cytometry

Bruno Jaggi, Steven Poon, and Branko Palcic
Appl. Opt. 26(16) 3325-3329 (1987)

Adaptive, associative, and self-organizing functions in neural computing

Teuvo Kohonen
Appl. Opt. 26(23) 4910-4918 (1987)