Abstract

A quantum weak measurement scheme based on a Mach–Zehnder interferometer is proposed to detect the concentration of glucose, bringing this mechanism into the field of biomedical sensing for the first time, to the best of our knowledge. With a Mach–Zehnder interferometer system, we can analyze tiny phase differences between the two paths by measuring spectrum shift. We measured the concentration of glucose with weak measurement to achieve a concentration resolution of $8.98\times {10}^{-5}\mathrm{g}/\mathrm{L}$ corresponding to a volume refractive index of $1.39\times {10}^{-8}\mathrm{RIU}$, which was more than five times higher than the resolution achieved by conventional interference, $4.99\times {10}^{-4}\mathrm{g}/\mathrm{L}$. In the detection of glucose concentration in the blood serum of mice, a resolution of $1.0136\times {10}^{-7}\mathrm{g}/\mathrm{L}$ for weak measurement was obtained.

© 2016 Optical Society of America

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