Automated interferometric synthetic aperture microscopy and computational adaptive optics for improved optical coherence tomography

Yang Xu; Yuan-Zhi Liu; Stephen A. Boppart; P. Scott Carney

doi:10.1364/AO.55.002034

Applied Optics
Vol. 55,
Issue 8,
pp. 2034-2041
(2016)
•https://doi.org/10.1364/AO.55.002034

Automated interferometric synthetic aperture microscopy and computational adaptive optics for improved optical coherence tomography

Yang Xu, Yuan-Zhi Liu, Stephen A. Boppart, and P. Scott Carney

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Yang Xu, Yuan-Zhi Liu, Stephen A. Boppart, and P. Scott Carney, "Automated interferometric synthetic aperture microscopy and computational adaptive optics for improved optical coherence tomography," Appl. Opt. 55, 2034-2041 (2016)

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- Imaging Systems
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About this Article
History
- Original Manuscript: December 15, 2015
- Revised Manuscript: January 27, 2016
- Manuscript Accepted: January 27, 2016
- Published: March 10, 2016

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Abstract

In this paper, we introduce an algorithm framework for the automation of interferometric synthetic aperture microscopy (ISAM). Under this framework, common processing steps such as dispersion correction, Fourier domain resampling, and computational adaptive optics aberration correction are carried out as metrics-assisted parameter search problems. We further present the results of this algorithm applied to phantom and biological tissue samples and compare with manually adjusted results. With the automated algorithm, near-optimal ISAM reconstruction can be achieved without manual adjustment. At the same time, the technical barrier for the nonexpert using ISAM imaging is also significantly lowered.

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Group	Label	Aberrations	Zernike Polynomials
I	1	Astigmatism	$z_{2}^{- 2} = \sqrt{6} ρ_{k}^{2} \sin 2 θ_{k}$
	2	Astigmatism	$z_{2}^{2} = \sqrt{6} ρ_{k}^{2} \cos 2 θ_{k}$
	3	Defocus	$z_{2}^{0} = \sqrt{3} (2 ρ_{k}^{2} - 1)$
II	4	Coma	$z_{3}^{- 1} = \sqrt{8} (3 ρ_{k}^{3} - ρ_{k}) \sin θ_{k}$
	5	Coma	$z_{3}^{1} = \sqrt{8} (3 ρ_{k}^{3} - ρ_{k}) \cos θ_{k}$
III	6	Spherical	$z_{4}^{0} = \sqrt{5} (6 ρ_{k}^{4} - 6 ρ_{k}^{2} + 1)$
	7	Defocus	$z_{2}^{0} = \sqrt{3} (2 ρ_{k}^{2} - 1)$

Sample\Metrics	Maximum Intensity	Image Power	Sparsity	High Spatial Frequency
Particle phantom	Good	Good	Good	Good
Biological tissue	Poor	Good	Intermediate	Good
Computational cost	Low	Intermediate	Intermediate	High

Group	Label	Aberrations	Zernike Polynomials
I	1	Astigmatism	$z_{2}^{- 2} = \sqrt{6} ρ_{k}^{2} \sin 2 θ_{k}$
	2	Astigmatism	$z_{2}^{2} = \sqrt{6} ρ_{k}^{2} \cos 2 θ_{k}$
	3	Defocus	$z_{2}^{0} = \sqrt{3} (2 ρ_{k}^{2} - 1)$
II	4	Coma	$z_{3}^{- 1} = \sqrt{8} (3 ρ_{k}^{3} - ρ_{k}) \sin θ_{k}$
	5	Coma	$z_{3}^{1} = \sqrt{8} (3 ρ_{k}^{3} - ρ_{k}) \cos θ_{k}$
III	6	Spherical	$z_{4}^{0} = \sqrt{5} (6 ρ_{k}^{4} - 6 ρ_{k}^{2} + 1)$
	7	Defocus	$z_{2}^{0} = \sqrt{3} (2 ρ_{k}^{2} - 1)$

Sample\Metrics	Maximum Intensity	Image Power	Sparsity	High Spatial Frequency
Particle phantom	Good	Good	Good	Good
Biological tissue	Poor	Good	Intermediate	Good
Computational cost	Low	Intermediate	Intermediate	High

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Applied Optics