Nanofluidic channels are of great interest for DNA sequencing, chromatography, and drug delivery. However, metrology of embedded or sealed nanochannels and measurement of their fill-state have remained extremely challenging. Existing techniques have been restricted to optical microscopy, which suffers from insufficient resolution, or scanning electron microscopy, which cannot measure sealed or embedded channels without cleaving the sample. Here, we demonstrate a novel method for accurately extracting nanochannel cross-sectional dimensions and monitoring fluid filling, utilizing spectroscopic ellipsometric scatterometry, combined with rigorous electromagnetic simulations. Our technique is capable of measuring channel dimensions with better than 5-nm accuracy and assessing channel filling within seconds. The developed technique is, thus, well suited for both process monitoring of channel fabrication as well as for studying complex phenomena of fluid flow through nanochannel structures.
© 2018 Optical Society of AmericaFull Article | PDF Article
More Like This
Shiyuan Liu, Weichao Du, Xiuguo Chen, Hao Jiang, and Chuanwei Zhang
Opt. Express 23(13) 17316-17329 (2015)
Appl. Opt. 46(12) 2219-2228 (2007)
Tatiana Novikova, Antonello De Martino, Sami Ben Hatit, and Bernard Drévillon
Appl. Opt. 45(16) 3688-3697 (2006)