Abstract

In this paper, we present a microstructured optofluidic in-fiber Raman sensor for the detection of quinolone antibiotic residue in a water environment based on Ag surface-enhanced Raman scattering (SERS) substrate grown on the surface of the suspended core of micro-hollow optical fiber (MHF). Here, MHF has a special structure with a suspended core and a microchannel inside, which can become a natural in-fiber optofluidic device. Meanwhile, the self-assembled Ag SERS substrate can be grown on the suspended core’s surface through chemical bonds, forming a microstructured optofluidic device with a Raman enhancement effect. Therefore, it can effectively detect the Raman signal of unlabeled trace quinolone antibiotic residue (ciprofloxacin and norfloxacin) inside the optical fiber. The results show that the ciprofloxacin and norfloxacin detection limits (LOD) are ${{10}^{- 10}}\;{\rm{M}}$ and ${{10}^{- 11}}\;{\rm{M}}$, respectively. Compared with the maximum residue limit (${3.01} \times {{10}^{- 7}}\;{\rm{mol}}/{\rm{L}}$) stipulated by the European Union, the results are much lower, and an ideal quantitative relationship can be obtained within the detection range. Significantly, this study provides an in-fiber microstructured optofluidic Raman sensor for the label-free detection of quinolone antibiotic residue, which will have good development prospects in the field of antibiotic water pollution environmental detection.

© 2021 Optical Society of America

Construction of optimized Au@Ag core-shell nanorods for ultralow SERS detection of antibiotic levofloxacin molecules

Yue Tian, Guanhua Li, Hua Zhang, Linlin Xu, Anxin Jiao, Feng Chen, and Ming Chen
Opt. Express 26(18) 23347-23358 (2018)

Optofluidic in-fiber integrated surface-enhanced Raman spectroscopy detection based on a hollow optical fiber with a suspended core

Danheng Gao, Xinghua Yang, Pingping Teng, Zhihai Liu, Jun Yang, Depeng Kong, Jianzhong Zhang, Meng Luo, Zhanao Li, Fengjun Tian, and Libo Yuan
Opt. Lett. 44(21) 5173-5176 (2019)

Development of monolayer AuNPs decorated on an optical fiber facet for SERS analysis

Ciyong Gu, Zhimin Zhao, and Pengcheng Shi
Appl. Opt. 60(3) 792-798 (2021)

Versatile flexible SERS substrate for in situ detection of contaminants in water and fruits based on Ag NPs decorated wrinkled PDMS film

Houjia Zhang, Zhaoyi Zhang, Hongjun Wang, Lili Huang, Zhenshan Yang, Yangzhi Wang, and Hefu Li
Opt. Express 31(13) 21025-21037 (2023)

In-fiber optofluidic online SERS detection of trace uremia toxin

Danheng Gao, Xinghua Yang, Pingping Teng, Meng Luo, Haoxin Zhang, Zhihai Liu, Jun Yang, Zhanao Li, Xingyue Wen, Libo Yuan, Kang Li, Mark Bowkett, and Nigel Copner
Opt. Lett. 46(5) 1101-1104 (2021)