Abstract
This paper describes fabrication and implementation of distributed optical fiber tip biosensor probes for simultaneously measuring label-free biomolecular interactions at multiple locations. Biosensor probes at the tip of a single-mode fiber are Fabry–Perot etalons that are functionalized with a capture layer for a specific biomolecule. A coherence multiplexing method is implemented to separate data collected from distributed biosensors in a single data stream. Multiplexing is achieved by using fiber tip biosensors of varying etalon lengths with the same or different capture layers for each biosensing channel. Experiments demonstrating simultaneous multi-channel recording of protein-to-protein interaction sensorgrams with fiber tip biosensor probes are presented.
© 2023 Optica Publishing Group
Full Article | PDF ArticleMore Like This
Sajal Chirvi, Zexuan Qiang, and Digant P. Davé
Opt. Lett. 37(14) 2952-2954 (2012)
Gyunel Rashidova, Meruyert Tilegen, Tri T. Pham, Aliya Bekmurzayeva, and Daniele Tosi
Biomed. Opt. Express 15(1) 185-198 (2024)
Yun Liu, Shimeng Chen, Qiang Liu, Jean-François Masson, and Wei Peng
Opt. Express 23(16) 20540-20548 (2015)