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DMSO synergized with sugars: optical clearing agent modulation of optical coherence tomography of skin tissues

Yuelin Wang, Wenhui Fang, Kai Zhang, and Zhiwei Men

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Abstract

The stratum corneum of the outermost skin is an important barrier impeding transdermal permeation, and permeation enhancers can reduce the barrier resistance of the stratum corneum and enhance the permeation of drugs in tissues. The optical imaging depth, signal intensity, and scattering coefficient variation rules of skin tissues in time dimension are obtained by using optical coherence tomography (OCT). The effect of optical clearing agents (OCAs) on OCT imaging is obtained by quantitatively analyzing the changes in the optical properties of tissues. D-fructose, one of the monosaccharides, and sucrose, one of the disaccharides, were selected for the ex vivo optical clearing experiments on pig skin tissues utilizing the dimethyl sulfoxide (DMSO) carrier effect. We find that DMSO synergized with sugars applied to skin tissue has a more significant increase in the optical imaging depth and signal intensity, and a reduction in the scattering coefficient with an increasing concentration of DMSO. DMSO with a high concentration and D-fructose with saturated concentration (10:1; v/v) effectively reduce light attenuation in OCT imaging and improve the image quality. This operation will also shorten the application time to minimize skin damage from hyperosmotic agents.

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Supplementary Material (6)

NameDescription
Data File 1       Signal intensity curves of different agents applied to pig skin at 1.2 mm depth; (a) and (b): D-fructose and sucrose mixed with DMSO of different concentrations, respectively
Data File 2       OCT normalized signal intensity, (a)-(d): 0.3 mm, 0.6 mm, 0.9 mm and 1.2 mm, respectively
Data File 3       Scattering coefficients of pig skin applied by different agents at different depths; (a) and (b): Treated by a mixture of D-fructose and DMSO of different concentrations at 0.3 mm and 1.2 mm depths, respectively; (c) and (d): Treated by a mixture of
Data File 4       Scattering coefficient of Group I and Group II applying to pig skin at different depths; (a)(b) indicate 0.9 mm and 1.2 mm, respectively.
Data File 5       Optical imaging depth of pig kins in Group I and Group II.
Data File 6       OCT signal slopes in the region of 0.8-1.2mm (a) Group I and (b) Group II.

Data availability

No data were generated or analyzed in the presented research.

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