Add to BibSonomy
Abstract
We propose a method for diagnosis of cirrhosis and hepatocellular carcinoma (HCC) by using a terahertz (THz) metamaterial (MM) biosensor. The biosensor has a resonance frequency at about 0.801 THz and can measure the concentration of alpha-fetoprotein (AFP) in serum. The sensitivity of the sensor is 124 GHz/refractive index unit (RIU), and the quality-factor (Q) is 6.913, respectively. When the surface of the biosensor is covered with healthy serum (${\rm{AFP}}\le {{7}}\;{\rm{ng/mL}}$), the maximum resonance frequency shift is 50 GHz. However, when it is covered with serum from patients with cirrhosis and early HCC (${\rm{AFP}}\gt{{7}}\;{\rm{ng/mL}}$), the resonance frequency shift is more than 59 GHz. Positive correlation exists between the frequency shift of the biosensor and serum levels of the AFP in the HCC patients. This study provides a method for quick diagnosis and prediction of cirrhosis and HCC.
© 2022 Optica Publishing Group
Full Article | PDF ArticleMore Like This
Sheng Ren, Yihua Zhao, Shiqi Wang, Zhenjiang Chen, Yunjian Xu, Zhenhao Mo, Xiaobin Wang, Binglin Shen, Junle Qu, Rui Hu, and Liwei Liu
Opt. Express 30(8) 12387-12396 (2022)
Haishun Liu, Ke Zhao, Xiangyi Liu, Zhenwei Zhang, Jingyu Qian, Cunlin Zhang, and Meiyan Liang
Biomed. Opt. Express 11(9) 5045-5059 (2020)
Weihao Fang, Zhengtai Ma, Xiaoqing Lv, Jian Liu, Weihua Pei, and Zhaoxin Geng
Opt. Express 30(10) 16630-16643 (2022)