Abstract

Flow-injection analysis has been utilized to generate surface-enhanced Raman spectra of pyridine, adenosine, and adenosine 3' monophosphate. These biologically important compounds have been recorded in a 10-μL spectroelectrochemical flow cell while under flowing conditions. Charge-coupled-device detection and low-power Ar⁺ laser excitation allowed an 1800-cm^-1 region to be observed with 10-s integration times. A computer-controlled potential waveform which efficiently adsorbs and desorbs the analytes at the electrode surface is described. The effects of the quantity of anodic charge passed during the <i>ex situ</i> and <i>in situ</i> roughening of the silver electrode on the SERS intensity are discussed. The limit of detection for 50-μL injections of adenosine under true dynamic conditions is less than 800 pmol. The technique yields both quantitative data and structural fingerprinting information for analytes eluting through the cell.

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