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Optica Publishing Group
  • Applied Spectroscopy
  • Vol. 50,
  • Issue 11,
  • pp. 1352-1359
  • (1996)

Spectrochemical Behavior of Carcinogenic Polycyclic Aromatic Hydrocarbons in Biological Systems. Part II: A Theoretical Rate Model for BaP Metabolism in Living Cells

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Abstract

An idealized model for the kinetics of benzo[<i>a</i>]pyrene (BaP) metabolism is established. As observed from experimental results, the BaP transfer from microcrystals to the cell membrane is definitely a first-order process. The rate constant of this process is signified as <i>k</i><sub>1</sub>. We describe the surface-midplane exchange as reversible and use rate constants <i>k</i><sub>2</sub> and <i>k</i><sub>3</sub> to describe the inward and outward diffusions, respectively. The metabolism is identified as an irreversible reaction with a rate constant <i>k</i><sub>4</sub>. If <i>k</i><sub>2</sub> and <i>k</i><sub>3</sub> are assumed to be fast and not rate determining, the effect of the metabolism rate, <i>k</i><sub>4</sub>, on the number density of BaP in the midplane of the microsomal membrane, <i>m</i><sub>3</sub>, can be estimated. If the metabolism rate is faster than or comparable to the distribution rates, <i>k</i><sub>2</sub> and <i>k</i><sub>3</sub>, the BaP concentration in the membrane midplane, <i>m</i><sub>3</sub>, will quickly be dissipated. But if <i>k</i><sub>4</sub> is extremely small, <i>m</i><sub>3</sub> will reach a plateau. Under conditions when <i>k</i><sub>2</sub> and <i>k</i><sub>3</sub> also play significant roles in determining the overall rate, more complicated patterns of <i>m</i><sub>3</sub> are expected.

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