Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group
  • Applied Spectroscopy
  • Vol. 72,
  • Issue 5,
  • pp. 715-724
  • (2018)

Near-Infrared Spectroscopy Screening to Allow Detection of Pathogenic Mitochondrial DNA Variants in Individuals with Unexplained Abnormal Fatigue: A Preliminary Study

Not Accessible

Your library or personal account may give you access

Abstract

Unexplained abnormal fatigue is characterized by chronic fatigue persisting for at least six months and not sufficiently explained by any recognized medical condition. In this pilot study, twelve individuals with abnormal fatigue remaining unexplained after thorough screening were investigated using a near-infrared (NIR) spectroscopy handgrip test. Four of them were found to have an abnormal oxygen extraction pattern similar to participants with documented mitochondrial myopathy. In three of the four individuals, diverse mitochondrial abnormalities were documented by spectrophotometric, immunocytological, fluorescent, and morphological analyses performed in skeletal muscle and in cultured skin fibroblasts. Three of the four participants with decreased muscular oxygen extraction were each shown to harbor a different homoplasmic pathogenic mitochondrial DNA point mutation (m.961T > C, m.1555A > G, m.14484T > C). In the fourth participant, the presence of multiple large mitochondrial DNA deletions was suspected in muscle tissue. In contrast, none of the eight abnormally fatigued participants with normal NIR spectroscopy results harbored either a pathogenic mitochondrial DNA point mutation or large deletions (P < 0.001). This pilot study shows that NIR spectroscopy may serve as a noninvasive screening tool to delineate a subgroup (of participants) with mitochondrial dysfunction among the large group of individuals with unexplained abnormal fatigue.

© 2018 The Author(s)

PDF Article
More Like This
Sustained fatigue assessment during isometric exercises with time-domain near infrared spectroscopy and surface electromyography signals

A. Scano, I. Pirovano, M. E. Manunza, L. Spinelli, D. Contini, A. Torricelli, and R. Re
Biomed. Opt. Express 11(12) 7357-7375 (2020)

Hemodynamics of the sternocleidomastoid measured with frequency domain near-infrared spectroscopy towards non-invasive monitoring during mechanical ventilation

Raeef Istfan, Carlos A. Gómez, Matthew Applegate, Dmitry Rozenberg, W. Darlene Reid, and Darren Roblyer
Biomed. Opt. Express 12(7) 4147-4162 (2021)

Age-related difference in muscle metabolism patterns during upper limb's encircling exercise: a near-infrared spectroscopy study

Hucheng Chen, Jianbin Liang, Wenzhu Huang, Anping Yang, Richong Pang, Chaochao Zhao, Kai Wu, Chong Wang, Kecheng Yan, YiZheng Zhang, Shuoshu Lin, Yuanrong Xie, Yuxiang Wu, and Jinyan Sun
Biomed. Opt. Express 13(9) 4737-4751 (2022)

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved