Abstract
In optical noninvasive glucose detection, how to detect the
glucose-caused signals from the constant human variations and disturbed
probing conditions is always the biggest challenge. Developing effective
measurement strategies is essential to realize the detection. A
near-infrared (NIR) spectroscopy-based strategy is studied to effectively
solve the in vivo measurement issues, obtaining clean blood glucose-caused
signals. Two solutions composing our strategy are applied to the NIR
spectroscopy-based measurement system to acquire clean raw signals in the
data collection, which are a customized high signal-to-noise ratio
multi-ring InGaAs detector to reduce the influence of human variations,
and a fixing and aiming method to reproduce a consistent measurement
condition. Seventeen cases of glucose tolerance test (GTT) on healthy and
diabetic volunteers were conducted to validate the strategy. The human
experiment results clearly show that the expected blood glucose changes
have been detected at 1550 nm. The average correlation coefficient of the
17 cases of GTT between light signal and glucose reference reaches 0.84.
The proposed measurement strategy is verified feasible for the glucose
detecting in vivo. The strategy provides references to further studies and
product developments for the NIR spectroscopy-based glucose measurement
and references to other optical measurements in vivo.
© 2022 The Author(s)
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