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Advances in optics for biotechnology, medicine and surgery

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Abstract

The editors introduce the Biomedical Optics Express feature issue, “Advances in Optics for Biotechnology, Medicine and Surgery,” which includes 12 contributions from attendees of the 2011 conference Advances in Optics for Biotechnology, Medicine and Surgery XII.

©2012 Optical Society of America

This feature issue represents topics covered at the 2011 Advances in Optics for Biotechnology, Medicine and Surgery XII conference in Naples, Florida, June 5–8, 2011. This was the 12th in a series of biennial meetings organized by Engineering Conferences International over the past 20 years. The editors of this feature issue were organizing chairs and co-chairs of the meeting, and submissions were considered from researchers who attended the meeting.

The cross section of papers within this feature issue demonstrates the great diversity of biophotonic techniques, while highlighting the continuing progress of our field towards providing true clinical value. Papers include new instrumentation approaches to clinical and intrasurgical imaging, including Clancy et al. [1], who present a new method to render three-dimensional surfaces during endoscopy using spectral encoding, and Solomon et al. [2], who present a system for high-speed diffuse optical tomography for sentinel lymph node resection. Larson et al. [3] present evaluation of a confocal microscope system for in vivo imaging of human skin and oral mucosa.

Novel microscopy development continues to be an important part of biomedical optics, providing tools for both basic research and clinical diagnostics. In this issue, Singh et al. [4] present an approach to improving the performance of structured light microscopy, while Sridharan et al. [5] demonstrate the potential of spatial light interference microscopy (SLIM) to allow simultaneous evaluation of the motility and growth of cells for developmental biology research. Lee et al. [6] highlight the great potential that optical techniques have for impact in the developing world, with a high-performance, inexpensive, and portable microscope for examination of biological specimens. Lim et al. [7] demonstrate a model of light scattering that could enable simple light scattering-based hematological analysis.

The conference highlighted the continued importance of optics for therapeutic applications, as represented by the work of Gualda et al. [8], who utilized two-photon microscopy to explore intrastromal ablation of the cornea, work very relevant to understanding and improving laser eye surgery.

Advances in multimodal photoacoustic methods are presented in Rousseau et al. [9], who combine photoacoustics ultrasonography. Tichauer et al. [10] demonstrate an approach for x-ray guided fluorescence tomography for small animal molecular imaging.

The continued importance of both quantitative image analysis and mathematical model development is also highlighted. Garcia-Allende et al. [11] use morphological analysis of optical coherence tomography (OCT) images for computer aided diagnosis of gastrointestinal tissues, and Gamm et al. [12], developed a model for estimation of absorption and scattering properties from fiber-optic based diffuse reflectance measurements.

Acknowledgments

The meeting was funded by generous support from the National Institutes of Biomedical Imaging and Bioengineering, the National Institute of Neurological Disorders and Stroke, the National Cancer Institute (award number R13EB012903), and the National Science Foundation (award number 1105324). Additional funding was provided by corporate sponsors: Chroma Technology Corporation, Coherent Inc, Fianium Ltd, Hamamatsu Photonics, Newport Corporation, Semrock Inc, Thorlabs Inc, and Andor Technology. It should be noted that the content of this issue is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Biomedical Imaging and Bioengineering or the National Institutes of Health.

References and links

1. N. T. Clancy, D. Stoyanov, L. Maier-Hein, A. Groch, G.-Z. Yang, and D. S. Elson, “Spectrally encoded fiber-based structured lighting probe for intraoperative 3D imaging,” Biomed. Opt. Express 2(11), 3119–3128 (2011). [CrossRef]   [PubMed]  

2. M. Solomon, B. R. White, R. E. Nothdruft, W. Akers, G. Sudlow, A. T. Eggebrecht, S. Achilefu, and J. P. Culver, “Video-rate fluorescence diffuse optical tomography for in vivo sentinel lymph node imaging,” Biomed. Opt. Express 2(12), 3267–3277 (2011). [CrossRef]   [PubMed]  

3. B. Larson, S. Abeytunge, and M. Rajadhyaksha, “Performance of full-pupil line-scanning reflectance confocal microscopy in human skin and oral mucosa in vivo,” Biomed. Opt. Express 2(7), 2055–2067 (2011). [CrossRef]   [PubMed]  

4. V. R. Singh, H. Choi, E. Y. S. Yew, D. Bhattacharya, L. Yuan, C. J. R. Sheppard, J. C. Rajapakse, G. Barbastathis, and P. T. C. So, “Improving signal-to-noise ratio of structured light microscopy based on photon reassignment,” Biomed. Opt. Express 3(1), 206–214 (2012). [CrossRef]   [PubMed]  

5. S. Sridharan, M. Mir, and G. Popescu, “Simultaneous optical measurements of cell motility and growth,” Biomed. Opt. Express 2(10), 2815–2820 (2011). [CrossRef]   [PubMed]  

6. M. Lee, O. Yaglidere, and A. Ozcan, “Field-portable reflection and transmission microscopy based on lensless holography,” Biomed. Opt. Express 2(9), 2721–2730 (2011). [CrossRef]   [PubMed]  

7. J. Lim, H. Ding, M. Mir, R. Zhu, K. Tangella, and G. Popescu, “Born approximation model for light scattering by red blood cells,” Biomed. Opt. Express 2(10), 2784–2791 (2011). [CrossRef]   [PubMed]  

8. E. J. Gualda, J. R. Vázquez de Aldana, M. C. Martínez-García, P. Moreno, J. Hernández-Toro, L. Roso, P. Artal, and J. M. Bueno, “Femtosecond infrared intrastromal ablation and backscattering-mode adaptive-optics multiphoton microscopy in chicken corneas,” Biomed. Opt. Express 2(11), 2950–2960 (2011). [CrossRef]   [PubMed]  

9. G. Rousseau, A. Blouin, and J.-P. Monchalin, “Non-contact photoacoustic tomography and ultrasonography for tissue imaging,” Biomed. Opt. Express 3(1), 16–25 (2012). [CrossRef]   [PubMed]  

10. K. M. Tichauer, R. W. Holt, F. El-Ghussein, Q. Zhu, H. Dehghani, F. Leblond, and B. W. Pogue, “Imaging workflow and calibration for CT-guided time-domain fluorescence tomography,” Biomed. Opt. Express 2(11), 3021–3036 (2011). [CrossRef]   [PubMed]  

11. P. B. Garcia-Allende, I. Amygdalos, H. Dhanapala, R. D. Goldin, G. B. Hanna, and D. S. Elson, “Morphological analysis of optical coherence tomography images for automated classification of gastrointestinal tissues,” Biomed. Opt. Express 2(10), 2821–2836 (2011). [CrossRef]   [PubMed]  

12. U. A. Gamm, S. C. Kanick, H. J. C. M. Sterenborg, D. J. Robinson, and A. Amelink, “Measurement of tissue scattering properties using multi-diameter single fiber reflectance spectroscopy: in silico sensitivity analysis,” Biomed. Opt. Express 2(11), 3150–3166 (2011). [CrossRef]   [PubMed]  

References

  • View by:

  1. N. T. Clancy, D. Stoyanov, L. Maier-Hein, A. Groch, G.-Z. Yang, and D. S. Elson, “Spectrally encoded fiber-based structured lighting probe for intraoperative 3D imaging,” Biomed. Opt. Express 2(11), 3119–3128 (2011).
    [Crossref] [PubMed]
  2. M. Solomon, B. R. White, R. E. Nothdruft, W. Akers, G. Sudlow, A. T. Eggebrecht, S. Achilefu, and J. P. Culver, “Video-rate fluorescence diffuse optical tomography for in vivo sentinel lymph node imaging,” Biomed. Opt. Express 2(12), 3267–3277 (2011).
    [Crossref] [PubMed]
  3. B. Larson, S. Abeytunge, and M. Rajadhyaksha, “Performance of full-pupil line-scanning reflectance confocal microscopy in human skin and oral mucosa in vivo,” Biomed. Opt. Express 2(7), 2055–2067 (2011).
    [Crossref] [PubMed]
  4. V. R. Singh, H. Choi, E. Y. S. Yew, D. Bhattacharya, L. Yuan, C. J. R. Sheppard, J. C. Rajapakse, G. Barbastathis, and P. T. C. So, “Improving signal-to-noise ratio of structured light microscopy based on photon reassignment,” Biomed. Opt. Express 3(1), 206–214 (2012).
    [Crossref] [PubMed]
  5. S. Sridharan, M. Mir, and G. Popescu, “Simultaneous optical measurements of cell motility and growth,” Biomed. Opt. Express 2(10), 2815–2820 (2011).
    [Crossref] [PubMed]
  6. M. Lee, O. Yaglidere, and A. Ozcan, “Field-portable reflection and transmission microscopy based on lensless holography,” Biomed. Opt. Express 2(9), 2721–2730 (2011).
    [Crossref] [PubMed]
  7. J. Lim, H. Ding, M. Mir, R. Zhu, K. Tangella, and G. Popescu, “Born approximation model for light scattering by red blood cells,” Biomed. Opt. Express 2(10), 2784–2791 (2011).
    [Crossref] [PubMed]
  8. E. J. Gualda, J. R. Vázquez de Aldana, M. C. Martínez-García, P. Moreno, J. Hernández-Toro, L. Roso, P. Artal, and J. M. Bueno, “Femtosecond infrared intrastromal ablation and backscattering-mode adaptive-optics multiphoton microscopy in chicken corneas,” Biomed. Opt. Express 2(11), 2950–2960 (2011).
    [Crossref] [PubMed]
  9. G. Rousseau, A. Blouin, and J.-P. Monchalin, “Non-contact photoacoustic tomography and ultrasonography for tissue imaging,” Biomed. Opt. Express 3(1), 16–25 (2012).
    [Crossref] [PubMed]
  10. K. M. Tichauer, R. W. Holt, F. El-Ghussein, Q. Zhu, H. Dehghani, F. Leblond, and B. W. Pogue, “Imaging workflow and calibration for CT-guided time-domain fluorescence tomography,” Biomed. Opt. Express 2(11), 3021–3036 (2011).
    [Crossref] [PubMed]
  11. P. B. Garcia-Allende, I. Amygdalos, H. Dhanapala, R. D. Goldin, G. B. Hanna, and D. S. Elson, “Morphological analysis of optical coherence tomography images for automated classification of gastrointestinal tissues,” Biomed. Opt. Express 2(10), 2821–2836 (2011).
    [Crossref] [PubMed]
  12. U. A. Gamm, S. C. Kanick, H. J. C. M. Sterenborg, D. J. Robinson, and A. Amelink, “Measurement of tissue scattering properties using multi-diameter single fiber reflectance spectroscopy: in silico sensitivity analysis,” Biomed. Opt. Express 2(11), 3150–3166 (2011).
    [Crossref] [PubMed]

2012 (2)

2011 (10)

K. M. Tichauer, R. W. Holt, F. El-Ghussein, Q. Zhu, H. Dehghani, F. Leblond, and B. W. Pogue, “Imaging workflow and calibration for CT-guided time-domain fluorescence tomography,” Biomed. Opt. Express 2(11), 3021–3036 (2011).
[Crossref] [PubMed]

P. B. Garcia-Allende, I. Amygdalos, H. Dhanapala, R. D. Goldin, G. B. Hanna, and D. S. Elson, “Morphological analysis of optical coherence tomography images for automated classification of gastrointestinal tissues,” Biomed. Opt. Express 2(10), 2821–2836 (2011).
[Crossref] [PubMed]

U. A. Gamm, S. C. Kanick, H. J. C. M. Sterenborg, D. J. Robinson, and A. Amelink, “Measurement of tissue scattering properties using multi-diameter single fiber reflectance spectroscopy: in silico sensitivity analysis,” Biomed. Opt. Express 2(11), 3150–3166 (2011).
[Crossref] [PubMed]

S. Sridharan, M. Mir, and G. Popescu, “Simultaneous optical measurements of cell motility and growth,” Biomed. Opt. Express 2(10), 2815–2820 (2011).
[Crossref] [PubMed]

M. Lee, O. Yaglidere, and A. Ozcan, “Field-portable reflection and transmission microscopy based on lensless holography,” Biomed. Opt. Express 2(9), 2721–2730 (2011).
[Crossref] [PubMed]

J. Lim, H. Ding, M. Mir, R. Zhu, K. Tangella, and G. Popescu, “Born approximation model for light scattering by red blood cells,” Biomed. Opt. Express 2(10), 2784–2791 (2011).
[Crossref] [PubMed]

E. J. Gualda, J. R. Vázquez de Aldana, M. C. Martínez-García, P. Moreno, J. Hernández-Toro, L. Roso, P. Artal, and J. M. Bueno, “Femtosecond infrared intrastromal ablation and backscattering-mode adaptive-optics multiphoton microscopy in chicken corneas,” Biomed. Opt. Express 2(11), 2950–2960 (2011).
[Crossref] [PubMed]

N. T. Clancy, D. Stoyanov, L. Maier-Hein, A. Groch, G.-Z. Yang, and D. S. Elson, “Spectrally encoded fiber-based structured lighting probe for intraoperative 3D imaging,” Biomed. Opt. Express 2(11), 3119–3128 (2011).
[Crossref] [PubMed]

M. Solomon, B. R. White, R. E. Nothdruft, W. Akers, G. Sudlow, A. T. Eggebrecht, S. Achilefu, and J. P. Culver, “Video-rate fluorescence diffuse optical tomography for in vivo sentinel lymph node imaging,” Biomed. Opt. Express 2(12), 3267–3277 (2011).
[Crossref] [PubMed]

B. Larson, S. Abeytunge, and M. Rajadhyaksha, “Performance of full-pupil line-scanning reflectance confocal microscopy in human skin and oral mucosa in vivo,” Biomed. Opt. Express 2(7), 2055–2067 (2011).
[Crossref] [PubMed]

Abeytunge, S.

Achilefu, S.

Akers, W.

Amelink, A.

Amygdalos, I.

Artal, P.

Barbastathis, G.

Bhattacharya, D.

Blouin, A.

Bueno, J. M.

Choi, H.

Clancy, N. T.

Culver, J. P.

Dehghani, H.

Dhanapala, H.

Ding, H.

Eggebrecht, A. T.

El-Ghussein, F.

Elson, D. S.

Gamm, U. A.

Garcia-Allende, P. B.

Goldin, R. D.

Groch, A.

Gualda, E. J.

Hanna, G. B.

Hernández-Toro, J.

Holt, R. W.

Kanick, S. C.

Larson, B.

Leblond, F.

Lee, M.

Lim, J.

Maier-Hein, L.

Martínez-García, M. C.

Mir, M.

Monchalin, J.-P.

Moreno, P.

Nothdruft, R. E.

Ozcan, A.

Pogue, B. W.

Popescu, G.

Rajadhyaksha, M.

Rajapakse, J. C.

Robinson, D. J.

Roso, L.

Rousseau, G.

Sheppard, C. J. R.

Singh, V. R.

So, P. T. C.

Solomon, M.

Sridharan, S.

Sterenborg, H. J. C. M.

Stoyanov, D.

Sudlow, G.

Tangella, K.

Tichauer, K. M.

Vázquez de Aldana, J. R.

White, B. R.

Yaglidere, O.

Yang, G.-Z.

Yew, E. Y. S.

Yuan, L.

Zhu, Q.

Zhu, R.

Biomed. Opt. Express (12)

N. T. Clancy, D. Stoyanov, L. Maier-Hein, A. Groch, G.-Z. Yang, and D. S. Elson, “Spectrally encoded fiber-based structured lighting probe for intraoperative 3D imaging,” Biomed. Opt. Express 2(11), 3119–3128 (2011).
[Crossref] [PubMed]

M. Solomon, B. R. White, R. E. Nothdruft, W. Akers, G. Sudlow, A. T. Eggebrecht, S. Achilefu, and J. P. Culver, “Video-rate fluorescence diffuse optical tomography for in vivo sentinel lymph node imaging,” Biomed. Opt. Express 2(12), 3267–3277 (2011).
[Crossref] [PubMed]

B. Larson, S. Abeytunge, and M. Rajadhyaksha, “Performance of full-pupil line-scanning reflectance confocal microscopy in human skin and oral mucosa in vivo,” Biomed. Opt. Express 2(7), 2055–2067 (2011).
[Crossref] [PubMed]

V. R. Singh, H. Choi, E. Y. S. Yew, D. Bhattacharya, L. Yuan, C. J. R. Sheppard, J. C. Rajapakse, G. Barbastathis, and P. T. C. So, “Improving signal-to-noise ratio of structured light microscopy based on photon reassignment,” Biomed. Opt. Express 3(1), 206–214 (2012).
[Crossref] [PubMed]

S. Sridharan, M. Mir, and G. Popescu, “Simultaneous optical measurements of cell motility and growth,” Biomed. Opt. Express 2(10), 2815–2820 (2011).
[Crossref] [PubMed]

M. Lee, O. Yaglidere, and A. Ozcan, “Field-portable reflection and transmission microscopy based on lensless holography,” Biomed. Opt. Express 2(9), 2721–2730 (2011).
[Crossref] [PubMed]

J. Lim, H. Ding, M. Mir, R. Zhu, K. Tangella, and G. Popescu, “Born approximation model for light scattering by red blood cells,” Biomed. Opt. Express 2(10), 2784–2791 (2011).
[Crossref] [PubMed]

E. J. Gualda, J. R. Vázquez de Aldana, M. C. Martínez-García, P. Moreno, J. Hernández-Toro, L. Roso, P. Artal, and J. M. Bueno, “Femtosecond infrared intrastromal ablation and backscattering-mode adaptive-optics multiphoton microscopy in chicken corneas,” Biomed. Opt. Express 2(11), 2950–2960 (2011).
[Crossref] [PubMed]

G. Rousseau, A. Blouin, and J.-P. Monchalin, “Non-contact photoacoustic tomography and ultrasonography for tissue imaging,” Biomed. Opt. Express 3(1), 16–25 (2012).
[Crossref] [PubMed]

K. M. Tichauer, R. W. Holt, F. El-Ghussein, Q. Zhu, H. Dehghani, F. Leblond, and B. W. Pogue, “Imaging workflow and calibration for CT-guided time-domain fluorescence tomography,” Biomed. Opt. Express 2(11), 3021–3036 (2011).
[Crossref] [PubMed]

P. B. Garcia-Allende, I. Amygdalos, H. Dhanapala, R. D. Goldin, G. B. Hanna, and D. S. Elson, “Morphological analysis of optical coherence tomography images for automated classification of gastrointestinal tissues,” Biomed. Opt. Express 2(10), 2821–2836 (2011).
[Crossref] [PubMed]

U. A. Gamm, S. C. Kanick, H. J. C. M. Sterenborg, D. J. Robinson, and A. Amelink, “Measurement of tissue scattering properties using multi-diameter single fiber reflectance spectroscopy: in silico sensitivity analysis,” Biomed. Opt. Express 2(11), 3150–3166 (2011).
[Crossref] [PubMed]

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