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Optica Publishing Group
  • Current Optics and Photonics
  • Vol. 3,
  • Issue 3,
  • pp. 256-262
  • (2019)

A Multi-detection Fluorescence Dye with 5-ALA and ICG Using Modified Light Emitting Diodes

Open Access Open Access

Abstract

Extensive tumor resection accompanied by radiotherapy and chemotherapy is the standard of care for malignant gliomas. However, there is a significant obstacle to the complete resection of the tumor due to the difficulty of distinguishing tumor and normal brain tissue with a conventional surgical microscope. Recently, multiple studies have shown the possibility of fluorescence-guided surgery in malignant gliomas. The most used fluorescence dyes for brain tumor surgery are 5-aminolevulinic acid (5-ALA) and indocyanine green (ICG). In this paper, a new fluorescence guided operation system, which can detect both 5-ALA and ICG fluorescent images simultaneously, is presented. This operation system consists of light emitting diodes (LEDs) which emits 410 nm and 740 nm wavelengths. We have performed experiments on rats in order to verify the operation of the newly developed operation system. Oral administration and imaging were performed to observe the fluorescence of 5-ALA and ICG fluorescence in rats. When LEDs at wavelengths of 410 nm and 740 nm were irradiated on rats, 628 nm wavelength with a violet fluorescence color and 825 nm wavelength with a red fluorescence color were expressed in 5-ALA and ICG fluorescent material, respectively, thus we were able to distinguish the tumor tissues easily. Previously, due to the poor resolution of the conventional surgical microscope and the fact that the color of the vein is similar to that of the tumor, the tumor resection margin was not easy to observe, thus increasing the likelihood for cancer recurrence. However, when the tumor is observed through the fluorescence guided operation system, it is possible to easily distinguish the color with the naked eye and it can be completely removed. Therefore, it is expected that surgical removal of cancerous tumors will be possible and surgical applications and surgical microscopes for cancer tumor removal surgery will be promising in the future.

© 2019 Optical Society of Korea

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References

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  1. F. Lefranc, N. Sadeghi, I. Camby, T. Metens, O. Dewitte, R. Kiss, "Present and potential future issues in glioblastoma treatment," Expert Rev. Anticancer Ther. 6, 719‒732 (2006)
    [Crossref]
  2. F. W. Boele, A. G. Rooney, R. Grant, M. Klein, "Psychiatric symptoms in glioma patients: from diagnosis to management," Neuropsychiatr. Dis. Treat. 11, 1413‒1420 (2015)
  3. T. Walbert, K. Chasteen, "Palliative and supportive care for glioma patients," Cancer Treat. Res. 163, 71‒84 (2015)
  4. W. Stummer, A. Novotny, H. Stepp, C. Goetz, K. Bise, H. J. Reulen, "Fluorescence-guided resection of glioblastoma muliforme utilizing 5-ALA-induced porphyrins: a prospective study in consecutive patients," J. Neurosurg. 93, 1003‒1013 (2000)
    [Crossref]
  5. C. T. Wen, Y. Y. Liu, H. Y. Fang, M. J. Hsieh, Y. K. Chao, "Image-guided video-assisted thoracoscopic small lung tumor resection using near-infrared marking," Surg. Endosc. 32, 4673‒4680 (2018)
    [Crossref]
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    [Crossref]
  8. W. M. Wells, P. Viola, H. Atsumi, S. Nakajima, R. Kikinis, "Multi-modal volume registration by maximization of mutual information," Med. Image Anal. 1, 35‒51 (1996)
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  9. H. E. Cline, W. E. Lorensen, R. Kikinis, F. A. Jolesz, "Three-dimensional segmentation of MR images of the head using probability and connectivity," J. Comput. Assist. Tomogr. 14, 1037‒1045 (1990)
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    [Crossref]
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    [Crossref]
  13. R. B. Price, D. Labrie, F. A. Rueggeberg, C. M. Felix, "Irradiance differences in the violet (405 nm) and blue (460 nm) spectral ranges among dental light-curing units," J. Esthet. Restor. Dent. 22, 363‒377 (2010)
    [Crossref]
  14. M. Atif, M. F. Alam, S. Firdous, S. S. Z. Zaidi, R. Suleman, M. Ikram, "Study of the efficacy of 5-ALA mediated photodynamic therapy on human rhabdomyosarcoma cell line (RD)," Laser Phys. Lett. 7, 757‒764 (2010)
    [Crossref]
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2018 (1)

C. T. Wen, Y. Y. Liu, H. Y. Fang, M. J. Hsieh, Y. K. Chao, "Image-guided video-assisted thoracoscopic small lung tumor resection using near-infrared marking," Surg. Endosc. 32, 4673‒4680 (2018)
[Crossref]

2017 (1)

C. Malkanthi, M. B. Dissanayake, "Brain tumor boundary segmentation of MR imaging using spatial domain image processing," Int. J. Innovation Educ. Res. 5, 1‒9 (2017)

2015 (2)

F. W. Boele, A. G. Rooney, R. Grant, M. Klein, "Psychiatric symptoms in glioma patients: from diagnosis to management," Neuropsychiatr. Dis. Treat. 11, 1413‒1420 (2015)

T. Walbert, K. Chasteen, "Palliative and supportive care for glioma patients," Cancer Treat. Res. 163, 71‒84 (2015)

2012 (1)

J. T. Alander, I. Kaartinen, A. Laakso, T. Patila, T. Spillmann, V. V. Tuchin, M. Venermo, Petri Välisuo, "A Review of Indocyanine Green Fluorescent Imaging in Surgery," Int. J. Biomed. Imaging 2012, 1‒26 (2012)

2010 (2)

R. B. Price, D. Labrie, F. A. Rueggeberg, C. M. Felix, "Irradiance differences in the violet (405 nm) and blue (460 nm) spectral ranges among dental light-curing units," J. Esthet. Restor. Dent. 22, 363‒377 (2010)
[Crossref]

M. Atif, M. F. Alam, S. Firdous, S. S. Z. Zaidi, R. Suleman, M. Ikram, "Study of the efficacy of 5-ALA mediated photodynamic therapy on human rhabdomyosarcoma cell line (RD)," Laser Phys. Lett. 7, 757‒764 (2010)
[Crossref]

2008 (1)

N. Unno, M. Suzuki, N. Yamamoto, K. Inuzuka, D. Sagara, M. Nishiyama, H. Tanaka, H. Konno, "Iundocyanine green fluorescence angiography for intraoperative assessment of blood flow: a feasibility study," Eur. J. Vasc. Endovasc. Surg. 35, 205‒207 (2008)
[Crossref]

2006 (1)

F. Lefranc, N. Sadeghi, I. Camby, T. Metens, O. Dewitte, R. Kiss, "Present and potential future issues in glioblastoma treatment," Expert Rev. Anticancer Ther. 6, 719‒732 (2006)
[Crossref]

2000 (2)

T. Desmettre, J. M. Devoisselle, S. Mordon, "Fluorescence properties and metabolic features of indocyanine green (ICG) as related to angiography," Surv. Ophthalmol. 45, 15‒27 (2000)
[Crossref]

W. Stummer, A. Novotny, H. Stepp, C. Goetz, K. Bise, H. J. Reulen, "Fluorescence-guided resection of glioblastoma muliforme utilizing 5-ALA-induced porphyrins: a prospective study in consecutive patients," J. Neurosurg. 93, 1003‒1013 (2000)
[Crossref]

1996 (1)

W. M. Wells, P. Viola, H. Atsumi, S. Nakajima, R. Kikinis, "Multi-modal volume registration by maximization of mutual information," Med. Image Anal. 1, 35‒51 (1996)
[Crossref]

1990 (1)

H. E. Cline, W. E. Lorensen, R. Kikinis, F. A. Jolesz, "Three-dimensional segmentation of MR images of the head using probability and connectivity," J. Comput. Assist. Tomogr. 14, 1037‒1045 (1990)
[Crossref]

1987 (1)

H. E. Cline, C. L. Dumoulin, W. E. Lorensen, H. R. Hart, S. Ludke, "3D reconstruction of the brain from magnetic resonance images using a connectivity algorithm," Magn. Reson. Imaging 5, 345‒352 (1987)
[Crossref]

Alam, M. F.

M. Atif, M. F. Alam, S. Firdous, S. S. Z. Zaidi, R. Suleman, M. Ikram, "Study of the efficacy of 5-ALA mediated photodynamic therapy on human rhabdomyosarcoma cell line (RD)," Laser Phys. Lett. 7, 757‒764 (2010)
[Crossref]

Alander, J. T.

J. T. Alander, I. Kaartinen, A. Laakso, T. Patila, T. Spillmann, V. V. Tuchin, M. Venermo, Petri Välisuo, "A Review of Indocyanine Green Fluorescent Imaging in Surgery," Int. J. Biomed. Imaging 2012, 1‒26 (2012)

Atif, M.

M. Atif, M. F. Alam, S. Firdous, S. S. Z. Zaidi, R. Suleman, M. Ikram, "Study of the efficacy of 5-ALA mediated photodynamic therapy on human rhabdomyosarcoma cell line (RD)," Laser Phys. Lett. 7, 757‒764 (2010)
[Crossref]

Atsumi, H.

W. M. Wells, P. Viola, H. Atsumi, S. Nakajima, R. Kikinis, "Multi-modal volume registration by maximization of mutual information," Med. Image Anal. 1, 35‒51 (1996)
[Crossref]

Bise, K.

W. Stummer, A. Novotny, H. Stepp, C. Goetz, K. Bise, H. J. Reulen, "Fluorescence-guided resection of glioblastoma muliforme utilizing 5-ALA-induced porphyrins: a prospective study in consecutive patients," J. Neurosurg. 93, 1003‒1013 (2000)
[Crossref]

Boele, F. W.

F. W. Boele, A. G. Rooney, R. Grant, M. Klein, "Psychiatric symptoms in glioma patients: from diagnosis to management," Neuropsychiatr. Dis. Treat. 11, 1413‒1420 (2015)

Camby, I.

F. Lefranc, N. Sadeghi, I. Camby, T. Metens, O. Dewitte, R. Kiss, "Present and potential future issues in glioblastoma treatment," Expert Rev. Anticancer Ther. 6, 719‒732 (2006)
[Crossref]

Chao, Y. K.

C. T. Wen, Y. Y. Liu, H. Y. Fang, M. J. Hsieh, Y. K. Chao, "Image-guided video-assisted thoracoscopic small lung tumor resection using near-infrared marking," Surg. Endosc. 32, 4673‒4680 (2018)
[Crossref]

Chasteen, K.

T. Walbert, K. Chasteen, "Palliative and supportive care for glioma patients," Cancer Treat. Res. 163, 71‒84 (2015)

Cline, H. E.

H. E. Cline, W. E. Lorensen, R. Kikinis, F. A. Jolesz, "Three-dimensional segmentation of MR images of the head using probability and connectivity," J. Comput. Assist. Tomogr. 14, 1037‒1045 (1990)
[Crossref]

H. E. Cline, C. L. Dumoulin, W. E. Lorensen, H. R. Hart, S. Ludke, "3D reconstruction of the brain from magnetic resonance images using a connectivity algorithm," Magn. Reson. Imaging 5, 345‒352 (1987)
[Crossref]

Desmettre, T.

T. Desmettre, J. M. Devoisselle, S. Mordon, "Fluorescence properties and metabolic features of indocyanine green (ICG) as related to angiography," Surv. Ophthalmol. 45, 15‒27 (2000)
[Crossref]

Devoisselle, J. M.

T. Desmettre, J. M. Devoisselle, S. Mordon, "Fluorescence properties and metabolic features of indocyanine green (ICG) as related to angiography," Surv. Ophthalmol. 45, 15‒27 (2000)
[Crossref]

Dewitte, O.

F. Lefranc, N. Sadeghi, I. Camby, T. Metens, O. Dewitte, R. Kiss, "Present and potential future issues in glioblastoma treatment," Expert Rev. Anticancer Ther. 6, 719‒732 (2006)
[Crossref]

Dissanayake, M. B.

C. Malkanthi, M. B. Dissanayake, "Brain tumor boundary segmentation of MR imaging using spatial domain image processing," Int. J. Innovation Educ. Res. 5, 1‒9 (2017)

Dumoulin, C. L.

H. E. Cline, C. L. Dumoulin, W. E. Lorensen, H. R. Hart, S. Ludke, "3D reconstruction of the brain from magnetic resonance images using a connectivity algorithm," Magn. Reson. Imaging 5, 345‒352 (1987)
[Crossref]

Fang, H. Y.

C. T. Wen, Y. Y. Liu, H. Y. Fang, M. J. Hsieh, Y. K. Chao, "Image-guided video-assisted thoracoscopic small lung tumor resection using near-infrared marking," Surg. Endosc. 32, 4673‒4680 (2018)
[Crossref]

Felix, C. M.

R. B. Price, D. Labrie, F. A. Rueggeberg, C. M. Felix, "Irradiance differences in the violet (405 nm) and blue (460 nm) spectral ranges among dental light-curing units," J. Esthet. Restor. Dent. 22, 363‒377 (2010)
[Crossref]

Firdous, S.

M. Atif, M. F. Alam, S. Firdous, S. S. Z. Zaidi, R. Suleman, M. Ikram, "Study of the efficacy of 5-ALA mediated photodynamic therapy on human rhabdomyosarcoma cell line (RD)," Laser Phys. Lett. 7, 757‒764 (2010)
[Crossref]

Goetz, C.

W. Stummer, A. Novotny, H. Stepp, C. Goetz, K. Bise, H. J. Reulen, "Fluorescence-guided resection of glioblastoma muliforme utilizing 5-ALA-induced porphyrins: a prospective study in consecutive patients," J. Neurosurg. 93, 1003‒1013 (2000)
[Crossref]

Grant, R.

F. W. Boele, A. G. Rooney, R. Grant, M. Klein, "Psychiatric symptoms in glioma patients: from diagnosis to management," Neuropsychiatr. Dis. Treat. 11, 1413‒1420 (2015)

Hamada, J. I.

B. L. Teng, M. Nakada, Y. Hayashi, T. Yoneyama, S. G. Zhao, J. I. Hamada, Clinical management and evolving novel therapeutic strategies for patients with brain tumors .

Hart, H. R.

H. E. Cline, C. L. Dumoulin, W. E. Lorensen, H. R. Hart, S. Ludke, "3D reconstruction of the brain from magnetic resonance images using a connectivity algorithm," Magn. Reson. Imaging 5, 345‒352 (1987)
[Crossref]

Hayashi, Y.

B. L. Teng, M. Nakada, Y. Hayashi, T. Yoneyama, S. G. Zhao, J. I. Hamada, Clinical management and evolving novel therapeutic strategies for patients with brain tumors .

Hsieh, M. J.

C. T. Wen, Y. Y. Liu, H. Y. Fang, M. J. Hsieh, Y. K. Chao, "Image-guided video-assisted thoracoscopic small lung tumor resection using near-infrared marking," Surg. Endosc. 32, 4673‒4680 (2018)
[Crossref]

Ikram, M.

M. Atif, M. F. Alam, S. Firdous, S. S. Z. Zaidi, R. Suleman, M. Ikram, "Study of the efficacy of 5-ALA mediated photodynamic therapy on human rhabdomyosarcoma cell line (RD)," Laser Phys. Lett. 7, 757‒764 (2010)
[Crossref]

Inuzuka, K.

N. Unno, M. Suzuki, N. Yamamoto, K. Inuzuka, D. Sagara, M. Nishiyama, H. Tanaka, H. Konno, "Iundocyanine green fluorescence angiography for intraoperative assessment of blood flow: a feasibility study," Eur. J. Vasc. Endovasc. Surg. 35, 205‒207 (2008)
[Crossref]

Jolesz, F. A.

H. E. Cline, W. E. Lorensen, R. Kikinis, F. A. Jolesz, "Three-dimensional segmentation of MR images of the head using probability and connectivity," J. Comput. Assist. Tomogr. 14, 1037‒1045 (1990)
[Crossref]

Kaartinen, I.

J. T. Alander, I. Kaartinen, A. Laakso, T. Patila, T. Spillmann, V. V. Tuchin, M. Venermo, Petri Välisuo, "A Review of Indocyanine Green Fluorescent Imaging in Surgery," Int. J. Biomed. Imaging 2012, 1‒26 (2012)

Kikinis, R.

W. M. Wells, P. Viola, H. Atsumi, S. Nakajima, R. Kikinis, "Multi-modal volume registration by maximization of mutual information," Med. Image Anal. 1, 35‒51 (1996)
[Crossref]

H. E. Cline, W. E. Lorensen, R. Kikinis, F. A. Jolesz, "Three-dimensional segmentation of MR images of the head using probability and connectivity," J. Comput. Assist. Tomogr. 14, 1037‒1045 (1990)
[Crossref]

Kiss, R.

F. Lefranc, N. Sadeghi, I. Camby, T. Metens, O. Dewitte, R. Kiss, "Present and potential future issues in glioblastoma treatment," Expert Rev. Anticancer Ther. 6, 719‒732 (2006)
[Crossref]

Klein, M.

F. W. Boele, A. G. Rooney, R. Grant, M. Klein, "Psychiatric symptoms in glioma patients: from diagnosis to management," Neuropsychiatr. Dis. Treat. 11, 1413‒1420 (2015)

Konno, H.

N. Unno, M. Suzuki, N. Yamamoto, K. Inuzuka, D. Sagara, M. Nishiyama, H. Tanaka, H. Konno, "Iundocyanine green fluorescence angiography for intraoperative assessment of blood flow: a feasibility study," Eur. J. Vasc. Endovasc. Surg. 35, 205‒207 (2008)
[Crossref]

Laakso, A.

J. T. Alander, I. Kaartinen, A. Laakso, T. Patila, T. Spillmann, V. V. Tuchin, M. Venermo, Petri Välisuo, "A Review of Indocyanine Green Fluorescent Imaging in Surgery," Int. J. Biomed. Imaging 2012, 1‒26 (2012)

Labrie, D.

R. B. Price, D. Labrie, F. A. Rueggeberg, C. M. Felix, "Irradiance differences in the violet (405 nm) and blue (460 nm) spectral ranges among dental light-curing units," J. Esthet. Restor. Dent. 22, 363‒377 (2010)
[Crossref]

Lefranc, F.

F. Lefranc, N. Sadeghi, I. Camby, T. Metens, O. Dewitte, R. Kiss, "Present and potential future issues in glioblastoma treatment," Expert Rev. Anticancer Ther. 6, 719‒732 (2006)
[Crossref]

Liu, Y. Y.

C. T. Wen, Y. Y. Liu, H. Y. Fang, M. J. Hsieh, Y. K. Chao, "Image-guided video-assisted thoracoscopic small lung tumor resection using near-infrared marking," Surg. Endosc. 32, 4673‒4680 (2018)
[Crossref]

Lorensen, W. E.

H. E. Cline, W. E. Lorensen, R. Kikinis, F. A. Jolesz, "Three-dimensional segmentation of MR images of the head using probability and connectivity," J. Comput. Assist. Tomogr. 14, 1037‒1045 (1990)
[Crossref]

H. E. Cline, C. L. Dumoulin, W. E. Lorensen, H. R. Hart, S. Ludke, "3D reconstruction of the brain from magnetic resonance images using a connectivity algorithm," Magn. Reson. Imaging 5, 345‒352 (1987)
[Crossref]

Ludke, S.

H. E. Cline, C. L. Dumoulin, W. E. Lorensen, H. R. Hart, S. Ludke, "3D reconstruction of the brain from magnetic resonance images using a connectivity algorithm," Magn. Reson. Imaging 5, 345‒352 (1987)
[Crossref]

Malkanthi, C.

C. Malkanthi, M. B. Dissanayake, "Brain tumor boundary segmentation of MR imaging using spatial domain image processing," Int. J. Innovation Educ. Res. 5, 1‒9 (2017)

Metens, T.

F. Lefranc, N. Sadeghi, I. Camby, T. Metens, O. Dewitte, R. Kiss, "Present and potential future issues in glioblastoma treatment," Expert Rev. Anticancer Ther. 6, 719‒732 (2006)
[Crossref]

Mordon, S.

T. Desmettre, J. M. Devoisselle, S. Mordon, "Fluorescence properties and metabolic features of indocyanine green (ICG) as related to angiography," Surv. Ophthalmol. 45, 15‒27 (2000)
[Crossref]

Nakada, M.

B. L. Teng, M. Nakada, Y. Hayashi, T. Yoneyama, S. G. Zhao, J. I. Hamada, Clinical management and evolving novel therapeutic strategies for patients with brain tumors .

Nakajima, S.

W. M. Wells, P. Viola, H. Atsumi, S. Nakajima, R. Kikinis, "Multi-modal volume registration by maximization of mutual information," Med. Image Anal. 1, 35‒51 (1996)
[Crossref]

Nishiyama, M.

N. Unno, M. Suzuki, N. Yamamoto, K. Inuzuka, D. Sagara, M. Nishiyama, H. Tanaka, H. Konno, "Iundocyanine green fluorescence angiography for intraoperative assessment of blood flow: a feasibility study," Eur. J. Vasc. Endovasc. Surg. 35, 205‒207 (2008)
[Crossref]

Novotny, A.

W. Stummer, A. Novotny, H. Stepp, C. Goetz, K. Bise, H. J. Reulen, "Fluorescence-guided resection of glioblastoma muliforme utilizing 5-ALA-induced porphyrins: a prospective study in consecutive patients," J. Neurosurg. 93, 1003‒1013 (2000)
[Crossref]

Patila, T.

J. T. Alander, I. Kaartinen, A. Laakso, T. Patila, T. Spillmann, V. V. Tuchin, M. Venermo, Petri Välisuo, "A Review of Indocyanine Green Fluorescent Imaging in Surgery," Int. J. Biomed. Imaging 2012, 1‒26 (2012)

Price, R. B.

R. B. Price, D. Labrie, F. A. Rueggeberg, C. M. Felix, "Irradiance differences in the violet (405 nm) and blue (460 nm) spectral ranges among dental light-curing units," J. Esthet. Restor. Dent. 22, 363‒377 (2010)
[Crossref]

Reulen, H. J.

W. Stummer, A. Novotny, H. Stepp, C. Goetz, K. Bise, H. J. Reulen, "Fluorescence-guided resection of glioblastoma muliforme utilizing 5-ALA-induced porphyrins: a prospective study in consecutive patients," J. Neurosurg. 93, 1003‒1013 (2000)
[Crossref]

Rooney, A. G.

F. W. Boele, A. G. Rooney, R. Grant, M. Klein, "Psychiatric symptoms in glioma patients: from diagnosis to management," Neuropsychiatr. Dis. Treat. 11, 1413‒1420 (2015)

Rueggeberg, F. A.

R. B. Price, D. Labrie, F. A. Rueggeberg, C. M. Felix, "Irradiance differences in the violet (405 nm) and blue (460 nm) spectral ranges among dental light-curing units," J. Esthet. Restor. Dent. 22, 363‒377 (2010)
[Crossref]

Sadeghi, N.

F. Lefranc, N. Sadeghi, I. Camby, T. Metens, O. Dewitte, R. Kiss, "Present and potential future issues in glioblastoma treatment," Expert Rev. Anticancer Ther. 6, 719‒732 (2006)
[Crossref]

Sagara, D.

N. Unno, M. Suzuki, N. Yamamoto, K. Inuzuka, D. Sagara, M. Nishiyama, H. Tanaka, H. Konno, "Iundocyanine green fluorescence angiography for intraoperative assessment of blood flow: a feasibility study," Eur. J. Vasc. Endovasc. Surg. 35, 205‒207 (2008)
[Crossref]

Spillmann, T.

J. T. Alander, I. Kaartinen, A. Laakso, T. Patila, T. Spillmann, V. V. Tuchin, M. Venermo, Petri Välisuo, "A Review of Indocyanine Green Fluorescent Imaging in Surgery," Int. J. Biomed. Imaging 2012, 1‒26 (2012)

Stepp, H.

W. Stummer, A. Novotny, H. Stepp, C. Goetz, K. Bise, H. J. Reulen, "Fluorescence-guided resection of glioblastoma muliforme utilizing 5-ALA-induced porphyrins: a prospective study in consecutive patients," J. Neurosurg. 93, 1003‒1013 (2000)
[Crossref]

Stummer, W.

W. Stummer, A. Novotny, H. Stepp, C. Goetz, K. Bise, H. J. Reulen, "Fluorescence-guided resection of glioblastoma muliforme utilizing 5-ALA-induced porphyrins: a prospective study in consecutive patients," J. Neurosurg. 93, 1003‒1013 (2000)
[Crossref]

Suleman, R.

M. Atif, M. F. Alam, S. Firdous, S. S. Z. Zaidi, R. Suleman, M. Ikram, "Study of the efficacy of 5-ALA mediated photodynamic therapy on human rhabdomyosarcoma cell line (RD)," Laser Phys. Lett. 7, 757‒764 (2010)
[Crossref]

Suzuki, M.

N. Unno, M. Suzuki, N. Yamamoto, K. Inuzuka, D. Sagara, M. Nishiyama, H. Tanaka, H. Konno, "Iundocyanine green fluorescence angiography for intraoperative assessment of blood flow: a feasibility study," Eur. J. Vasc. Endovasc. Surg. 35, 205‒207 (2008)
[Crossref]

Tanaka, H.

N. Unno, M. Suzuki, N. Yamamoto, K. Inuzuka, D. Sagara, M. Nishiyama, H. Tanaka, H. Konno, "Iundocyanine green fluorescence angiography for intraoperative assessment of blood flow: a feasibility study," Eur. J. Vasc. Endovasc. Surg. 35, 205‒207 (2008)
[Crossref]

Teng, B. L.

B. L. Teng, M. Nakada, Y. Hayashi, T. Yoneyama, S. G. Zhao, J. I. Hamada, Clinical management and evolving novel therapeutic strategies for patients with brain tumors .

Tuchin, V. V.

J. T. Alander, I. Kaartinen, A. Laakso, T. Patila, T. Spillmann, V. V. Tuchin, M. Venermo, Petri Välisuo, "A Review of Indocyanine Green Fluorescent Imaging in Surgery," Int. J. Biomed. Imaging 2012, 1‒26 (2012)

Unno, N.

N. Unno, M. Suzuki, N. Yamamoto, K. Inuzuka, D. Sagara, M. Nishiyama, H. Tanaka, H. Konno, "Iundocyanine green fluorescence angiography for intraoperative assessment of blood flow: a feasibility study," Eur. J. Vasc. Endovasc. Surg. 35, 205‒207 (2008)
[Crossref]

Välisuo, Petri

J. T. Alander, I. Kaartinen, A. Laakso, T. Patila, T. Spillmann, V. V. Tuchin, M. Venermo, Petri Välisuo, "A Review of Indocyanine Green Fluorescent Imaging in Surgery," Int. J. Biomed. Imaging 2012, 1‒26 (2012)

Venermo, M.

J. T. Alander, I. Kaartinen, A. Laakso, T. Patila, T. Spillmann, V. V. Tuchin, M. Venermo, Petri Välisuo, "A Review of Indocyanine Green Fluorescent Imaging in Surgery," Int. J. Biomed. Imaging 2012, 1‒26 (2012)

Viola, P.

W. M. Wells, P. Viola, H. Atsumi, S. Nakajima, R. Kikinis, "Multi-modal volume registration by maximization of mutual information," Med. Image Anal. 1, 35‒51 (1996)
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Walbert, T.

T. Walbert, K. Chasteen, "Palliative and supportive care for glioma patients," Cancer Treat. Res. 163, 71‒84 (2015)

Wells, W. M.

W. M. Wells, P. Viola, H. Atsumi, S. Nakajima, R. Kikinis, "Multi-modal volume registration by maximization of mutual information," Med. Image Anal. 1, 35‒51 (1996)
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Wen, C. T.

C. T. Wen, Y. Y. Liu, H. Y. Fang, M. J. Hsieh, Y. K. Chao, "Image-guided video-assisted thoracoscopic small lung tumor resection using near-infrared marking," Surg. Endosc. 32, 4673‒4680 (2018)
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Yamamoto, N.

N. Unno, M. Suzuki, N. Yamamoto, K. Inuzuka, D. Sagara, M. Nishiyama, H. Tanaka, H. Konno, "Iundocyanine green fluorescence angiography for intraoperative assessment of blood flow: a feasibility study," Eur. J. Vasc. Endovasc. Surg. 35, 205‒207 (2008)
[Crossref]

Yoneyama, T.

B. L. Teng, M. Nakada, Y. Hayashi, T. Yoneyama, S. G. Zhao, J. I. Hamada, Clinical management and evolving novel therapeutic strategies for patients with brain tumors .

Zaidi, S. S. Z.

M. Atif, M. F. Alam, S. Firdous, S. S. Z. Zaidi, R. Suleman, M. Ikram, "Study of the efficacy of 5-ALA mediated photodynamic therapy on human rhabdomyosarcoma cell line (RD)," Laser Phys. Lett. 7, 757‒764 (2010)
[Crossref]

Zhao, S. G.

B. L. Teng, M. Nakada, Y. Hayashi, T. Yoneyama, S. G. Zhao, J. I. Hamada, Clinical management and evolving novel therapeutic strategies for patients with brain tumors .

Cancer Treat. Res. (1)

T. Walbert, K. Chasteen, "Palliative and supportive care for glioma patients," Cancer Treat. Res. 163, 71‒84 (2015)

Eur. J. Vasc. Endovasc. Surg. (1)

N. Unno, M. Suzuki, N. Yamamoto, K. Inuzuka, D. Sagara, M. Nishiyama, H. Tanaka, H. Konno, "Iundocyanine green fluorescence angiography for intraoperative assessment of blood flow: a feasibility study," Eur. J. Vasc. Endovasc. Surg. 35, 205‒207 (2008)
[Crossref]

Expert Rev. Anticancer Ther. (1)

F. Lefranc, N. Sadeghi, I. Camby, T. Metens, O. Dewitte, R. Kiss, "Present and potential future issues in glioblastoma treatment," Expert Rev. Anticancer Ther. 6, 719‒732 (2006)
[Crossref]

Int. J. Biomed. Imaging (1)

J. T. Alander, I. Kaartinen, A. Laakso, T. Patila, T. Spillmann, V. V. Tuchin, M. Venermo, Petri Välisuo, "A Review of Indocyanine Green Fluorescent Imaging in Surgery," Int. J. Biomed. Imaging 2012, 1‒26 (2012)

Int. J. Innovation Educ. Res. (1)

C. Malkanthi, M. B. Dissanayake, "Brain tumor boundary segmentation of MR imaging using spatial domain image processing," Int. J. Innovation Educ. Res. 5, 1‒9 (2017)

J. Comput. Assist. Tomogr. (1)

H. E. Cline, W. E. Lorensen, R. Kikinis, F. A. Jolesz, "Three-dimensional segmentation of MR images of the head using probability and connectivity," J. Comput. Assist. Tomogr. 14, 1037‒1045 (1990)
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J. Esthet. Restor. Dent. (1)

R. B. Price, D. Labrie, F. A. Rueggeberg, C. M. Felix, "Irradiance differences in the violet (405 nm) and blue (460 nm) spectral ranges among dental light-curing units," J. Esthet. Restor. Dent. 22, 363‒377 (2010)
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J. Neurosurg. (1)

W. Stummer, A. Novotny, H. Stepp, C. Goetz, K. Bise, H. J. Reulen, "Fluorescence-guided resection of glioblastoma muliforme utilizing 5-ALA-induced porphyrins: a prospective study in consecutive patients," J. Neurosurg. 93, 1003‒1013 (2000)
[Crossref]

Laser Phys. Lett. (1)

M. Atif, M. F. Alam, S. Firdous, S. S. Z. Zaidi, R. Suleman, M. Ikram, "Study of the efficacy of 5-ALA mediated photodynamic therapy on human rhabdomyosarcoma cell line (RD)," Laser Phys. Lett. 7, 757‒764 (2010)
[Crossref]

Magn. Reson. Imaging (1)

H. E. Cline, C. L. Dumoulin, W. E. Lorensen, H. R. Hart, S. Ludke, "3D reconstruction of the brain from magnetic resonance images using a connectivity algorithm," Magn. Reson. Imaging 5, 345‒352 (1987)
[Crossref]

Med. Image Anal. (1)

W. M. Wells, P. Viola, H. Atsumi, S. Nakajima, R. Kikinis, "Multi-modal volume registration by maximization of mutual information," Med. Image Anal. 1, 35‒51 (1996)
[Crossref]

Neuropsychiatr. Dis. Treat. (1)

F. W. Boele, A. G. Rooney, R. Grant, M. Klein, "Psychiatric symptoms in glioma patients: from diagnosis to management," Neuropsychiatr. Dis. Treat. 11, 1413‒1420 (2015)

Surg. Endosc. (1)

C. T. Wen, Y. Y. Liu, H. Y. Fang, M. J. Hsieh, Y. K. Chao, "Image-guided video-assisted thoracoscopic small lung tumor resection using near-infrared marking," Surg. Endosc. 32, 4673‒4680 (2018)
[Crossref]

Surv. Ophthalmol. (1)

T. Desmettre, J. M. Devoisselle, S. Mordon, "Fluorescence properties and metabolic features of indocyanine green (ICG) as related to angiography," Surv. Ophthalmol. 45, 15‒27 (2000)
[Crossref]

Other (2)

Indocyanine Green for Injection, USP Sterile NDA 11-525-S-017 .

B. L. Teng, M. Nakada, Y. Hayashi, T. Yoneyama, S. G. Zhao, J. I. Hamada, Clinical management and evolving novel therapeutic strategies for patients with brain tumors .

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