Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group
  • Current Optics and Photonics
  • Vol. 3,
  • Issue 1,
  • pp. 54-65
  • (2019)

Vascular Morphometric Changes During Tumor Growth and Chemotherapy in a Murine Mammary Tumor Model Using OCT Angiography: a Preliminary Study

Open Access Open Access


To develop a biomarker predicting tumor treatment efficacy is helpful to reduce time, medical expenditure, and efforts in oncology therapy. In clinics, microvessel density using immunohistochemistry has been proposed as an indicator that correlates with both tumor size and metastasis of cancer. In the preclinical study, we hypothesized that vascular morphometrics using optical coherence tomography angiography (OCTA) could be potential indicators to estimate the treatment efficacy of breast cancer. To verify this hypothesis, a 13762-MAT-B-III rat breast tumor was grown in a dorsal skinfold window chamber which was applied to a nude mouse, and the change in vascular morphology was longitudinally monitored during tumor growth and metronomic cyclophosphamide treatment. Based on the daily OCTA maximum intensity projection map, multiple vessel parameters (vessel skeleton density, vessel diameter index, fractal dimension, and lacunarity) were compared with the tumor size in no tumor, treated tumor, and untreated tumor cases. Although each case has only one animal, we found that the vessel skeleton density (VSD), vessel diameter index and fractal dimension (FD) tended to be positively correlated with tumor size while lacunarity showed a partially negative correlation. Moreover, we observed that the changes in the VSD and FD are prior to the morphological change of the tumor. This feasibility study would be helpful in evaluating the tumor vascular response to treatment in preclinical settings.

© 2019 Optical Society of Korea

PDF Article
More Like This
Quantitative analysis of vascular changes during photoimmunotherapy using speckle variance optical coherence tomography (SV-OCT)

Shulian Wu, Ryuhei Okada, Yi Liu, Yuhong Fang, Feng Yan, Chen Wang, Hui Li, Hisataka Kobayashi, Yu Chen, and Qinggong Tang
Biomed. Opt. Express 12(4) 1804-1820 (2021)

In vivo assessment of functional and morphological alterations in tumors under treatment using OCT-angiography combined with OCT-elastography

Marina A. Sirotkina, Ekaterina V. Gubarkova, Anton A. Plekhanov, Alexander A. Sovetsky, Vadim V. Elagin, Alexander L. Matveyev, Lev A. Matveev, Sergey S. Kuznetsov, Elena V. Zagaynova, Natalia D. Gladkova, and Vladimir Y. Zaitsev
Biomed. Opt. Express 11(3) 1365-1382 (2020)

Segregation of neuronal-vascular components in a retinal nerve fiber layer for thickness measurement using OCT and OCT angiography

Ai Ping Yow, Bingyao Tan, Jacqueline Chua, Rahat Husain, Leopold Schmetterer, and Damon Wong
Biomed. Opt. Express 12(6) 3228-3240 (2021)

Cited By

Optica participates in Crossref's Cited-By Linking service. Citing articles from Optica Publishing Group journals and other participating publishers are listed here.

Select as filters

Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All rights reserved, including rights for text and data mining and training of artificial technologies or similar technologies.