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Optica Publishing Group
  • Current Optics and Photonics
  • Vol. 3,
  • Issue 1,
  • pp. 54-65
  • (2019)

Vascular Morphometric Changes During Tumor Growth and Chemotherapy in a Murine Mammary Tumor Model Using OCT Angiography: a Preliminary Study

Open Access Open Access

Abstract

To develop a biomarker predicting tumor treatment efficacy is helpful to reduce time, medical expenditure, and efforts in oncology therapy. In clinics, microvessel density using immunohistochemistry has been proposed as an indicator that correlates with both tumor size and metastasis of cancer. In the preclinical study, we hypothesized that vascular morphometrics using optical coherence tomography angiography (OCTA) could be potential indicators to estimate the treatment efficacy of breast cancer. To verify this hypothesis, a 13762-MAT-B-III rat breast tumor was grown in a dorsal skinfold window chamber which was applied to a nude mouse, and the change in vascular morphology was longitudinally monitored during tumor growth and metronomic cyclophosphamide treatment. Based on the daily OCTA maximum intensity projection map, multiple vessel parameters (vessel skeleton density, vessel diameter index, fractal dimension, and lacunarity) were compared with the tumor size in no tumor, treated tumor, and untreated tumor cases. Although each case has only one animal, we found that the vessel skeleton density (VSD), vessel diameter index and fractal dimension (FD) tended to be positively correlated with tumor size while lacunarity showed a partially negative correlation. Moreover, we observed that the changes in the VSD and FD are prior to the morphological change of the tumor. This feasibility study would be helpful in evaluating the tumor vascular response to treatment in preclinical settings.

© 2019 Optical Society of Korea

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References

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2018 (3)

A. Y. Park, B. K. Seo, O. H. Woo, K. S. Jung, K. R. Cho, E. K. Park, S. H. Cha, J. Cha, "The utility of ultrasound superb microvascular imaging for evaluation of breast tumour vascularity: Comparison with colour and power Doppler imaging regarding diagnostic performance," Clin. Radiol. 73, 304‒311 (2018)
[Crossref]

J. Yang, C. Liao, Y. Liu, G. Yang, T. Ke, Y. Ding, L. Qinqing, "MR imaging biomarkers evaluating vascular normalization window after anti-vessel treatment," Oncotarget 9, 11964‒11976 (2018)

A. F. Martinez, S. S. M. Iii, M. Lee, H. A. Murphy, B. T. Crouch, H. L. Martin, A. Erkanli, N. Rajaram, K. A. Ashcraft, A. N. Fontanella, M. W. Dewhirst, N. Ramanujam, "Metaboloptics: visualization of the tumor functional landscape via metabolic and vascular imaging," Sci. Rep. 8, 1‒15 (2018)
[Crossref]

2017 (2)

R. L. Siegel, K. D. Miller, A. Jemal, "Cancer statistics 2017," CA. Cancer J. Clin. 67, 7‒30 (2017)
[Crossref]

S. Lee, H. Jeong, M. Seong, J. G. Kim, "Change of tumor vascular reactivity during tumor growth and postchemotherapy observed by near-infrared spectroscopy," J. Biomed. Opt. 22, 121603 (2017)
[Crossref]

2016 (2)

E. Sener, S. Sipal, C. Gundogdu, "Comparison of microvessel density with prognostic factors in invasive ductal carcinomas of the breast," Turk Patoloji Derg. 32, 164‒170 (2016)

Z. Chu, J. Lin, C. Gao, C. Xin, Q. Zhang, C.-L. Chen, L. Roisman, G. Gregori, P. J. Rosenfeld, R. K. Wang, "Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography," J. Biomed. Opt. 21, 066008 (2016)
[Crossref]

2015 (3)

J. Pan, L. Cheng, X. Bi, X. Zhang, S. Liu, X. Bai, F. Li, A. Z. Zhao, "Elevation of ω-3 polyunsaturated fatty acids attenuates PTEN-deficiency induced endometrial cancer development through regulation of COX-2 and PGE2 production," Sci Rep 5, 1‒12 (2015)

J. N. Bharti, P. Rani, V. Kamal, P. N. Agarwal, "Angiogenesis in breast cancer and its correlation with estrogen progesterone receptors and other prognostic factors," J. Clin. Diagn. Res. 9, 5‒7 (2015)

M. G. Hyeon, H.-J. Kim, B.-M. Kim, T. J. Eom, "Spectral domain optical coherence tomography with balanced detection using single line-scan camera and optical delay line," Opt. Express 23, 23079‒23091 (2015)
[Crossref]

2014 (2)

S. Yousefi, R. K. Wang, "Simultaneous estimation of bidirectional particle flow and relative flux using MUSIC-OCT: phantom studies," Phys. Med. Biol. 59, 6693‒6708 (2014)
[Crossref]

A. S. Nam, I. Chico-Calero, B. J. Vakoc, "Complex differential variance algorithm for optical coherence tomography angiography," Biomed. Opt. Express 5, 3822‒3832 (2014)
[Crossref]

2013 (1)

2012 (3)

G. Liu, A. J. Lin, B. J. Tromberg, Z. Chen, "A comparison of Doppler optical coherence tomography methods," Biomed. Opt. Express 3, 2669‒2680 (2012)
[Crossref]

C. A. Schneider, W. S. Rasband, K. W. Eliceiri, "NIH Image to ImageJ: 25 years of image analysis," Nat. Methods 9, 671‒675 (2012)
[Crossref]

B. J. Vakoc, D. Fukumura, R. K. Jain, B. E. Bouma, "Cancer imaging by optical coherence tomography: preclinical progress and clinical potential," Nat. Rev. Cancer 12, 363‒368 (2012)
[Crossref]

2011 (2)

R. T. Ullrich, J. F. Jikeli, M. Diedenhofen, P. Bo, M. Unruh, S. Vollmar, M. Hoehn, "In-vivo visualization of tumor microvessel density and response to anti-angiogenic treatment by high resolution MRI in Mice," PLoS One 6, e19592 (2011)
[Crossref]

G. M. Palmer, A. N. Fontanella, S. Shan, G. Hanna, G. Zhang, C. L. Fraser, M. W. Dewhirst, "In vivo optical molecular imaging and analysis in mice using dorsal window chamber models applied to hypoxia vasculature and fluorescent reporters," Nat. Protoc. 6, 1355‒1366 (2011)
[Crossref]

2010 (1)

2009 (1)

B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, B. E. Bouma, "Three dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging," Nat. Med. 15, 1219‒1223 (2009)
[Crossref]

2003 (1)

S. Tsutsui, M. Kume, S. Era, "Prognostic value of microvessel density in invasive ductal carcinoma of the breast," Breast Cancer 10, 312‒319 (2003)
[Crossref]

2000 (1)

C. M. Brophy, "The dynamic regulation of blood vessel caliber," J. Vasc. Surg. 31, 391‒395 (2000)
[Crossref]

1997 (1)

Y. Gazit, J. W. Baish, N. Safabakhsh, M. Leunig, L. T. Baxter, R. K. Jain, "Fractal characteristics of tumor vascular architecture during tumor growth and regression," Microcirculation 4, 395‒402 (1997)
[Crossref]

1995 (1)

Y. Gazit, D. A. Berk, M. Leunig, L. T. Baxter, R. K. Jain, "Scale-invariant behavior and vascular network formation in normal and tumor tissue," Phys. Rev. Lett. 75, 2428‒2431 (1995)
[Crossref]

1993 (1)

Y. Li, H. Yu, L. Zhang, H. Li, "Effects of various vasoactive agents on tumor blood flow in rat," Chin. J. Cancer Res. 5, 116‒121 (1993)
[Crossref]

1992 (1)

M. Leunig, F. Yuan, M. D. Menger, Y. Boucher, A. E. Goetz, K. Messmer, R. K. Jain, "Angiogenesis microvascular architecture microhemodynamics and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice," Cancer Res. 52, 6553‒6560 (1992)

Agarwal, P. N.

J. N. Bharti, P. Rani, V. Kamal, P. N. Agarwal, "Angiogenesis in breast cancer and its correlation with estrogen progesterone receptors and other prognostic factors," J. Clin. Diagn. Res. 9, 5‒7 (2015)

Annapragada, A.

K. B. Ghaghada, Z. Starosolski, I. Stupin, P. Sarkar, A. Annapragada, Interrogation of evolving tumor vasculature using high-resolution CT imaging and a nanoparticle contrast agent .

Appleton, C. M.

L. Lin, P. Hu, J. Shi, K. I. Maslov, L. V. Wang, C. M. Appleton, Clinical photoacoustic computed tomography of the human breast in vivo within a single breath hold .

Ashcraft, K. A.

A. F. Martinez, S. S. M. Iii, M. Lee, H. A. Murphy, B. T. Crouch, H. L. Martin, A. Erkanli, N. Rajaram, K. A. Ashcraft, A. N. Fontanella, M. W. Dewhirst, N. Ramanujam, "Metaboloptics: visualization of the tumor functional landscape via metabolic and vascular imaging," Sci. Rep. 8, 1‒15 (2018)
[Crossref]

Bai, X.

J. Pan, L. Cheng, X. Bi, X. Zhang, S. Liu, X. Bai, F. Li, A. Z. Zhao, "Elevation of ω-3 polyunsaturated fatty acids attenuates PTEN-deficiency induced endometrial cancer development through regulation of COX-2 and PGE2 production," Sci Rep 5, 1‒12 (2015)

Baish, J. W.

Y. Gazit, J. W. Baish, N. Safabakhsh, M. Leunig, L. T. Baxter, R. K. Jain, "Fractal characteristics of tumor vascular architecture during tumor growth and regression," Microcirculation 4, 395‒402 (1997)
[Crossref]

Bartlett, L. A.

B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, B. E. Bouma, "Three dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging," Nat. Med. 15, 1219‒1223 (2009)
[Crossref]

Baxter, L. T.

Y. Gazit, J. W. Baish, N. Safabakhsh, M. Leunig, L. T. Baxter, R. K. Jain, "Fractal characteristics of tumor vascular architecture during tumor growth and regression," Microcirculation 4, 395‒402 (1997)
[Crossref]

Y. Gazit, D. A. Berk, M. Leunig, L. T. Baxter, R. K. Jain, "Scale-invariant behavior and vascular network formation in normal and tumor tissue," Phys. Rev. Lett. 75, 2428‒2431 (1995)
[Crossref]

Berk, D. A.

Y. Gazit, D. A. Berk, M. Leunig, L. T. Baxter, R. K. Jain, "Scale-invariant behavior and vascular network formation in normal and tumor tissue," Phys. Rev. Lett. 75, 2428‒2431 (1995)
[Crossref]

Bharti, J. N.

J. N. Bharti, P. Rani, V. Kamal, P. N. Agarwal, "Angiogenesis in breast cancer and its correlation with estrogen progesterone receptors and other prognostic factors," J. Clin. Diagn. Res. 9, 5‒7 (2015)

Bi, X.

J. Pan, L. Cheng, X. Bi, X. Zhang, S. Liu, X. Bai, F. Li, A. Z. Zhao, "Elevation of ω-3 polyunsaturated fatty acids attenuates PTEN-deficiency induced endometrial cancer development through regulation of COX-2 and PGE2 production," Sci Rep 5, 1‒12 (2015)

Bo, P.

R. T. Ullrich, J. F. Jikeli, M. Diedenhofen, P. Bo, M. Unruh, S. Vollmar, M. Hoehn, "In-vivo visualization of tumor microvessel density and response to anti-angiogenic treatment by high resolution MRI in Mice," PLoS One 6, e19592 (2011)
[Crossref]

Boucher, Y.

M. Leunig, F. Yuan, M. D. Menger, Y. Boucher, A. E. Goetz, K. Messmer, R. K. Jain, "Angiogenesis microvascular architecture microhemodynamics and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice," Cancer Res. 52, 6553‒6560 (1992)

Bouma, B. E.

B. J. Vakoc, D. Fukumura, R. K. Jain, B. E. Bouma, "Cancer imaging by optical coherence tomography: preclinical progress and clinical potential," Nat. Rev. Cancer 12, 363‒368 (2012)
[Crossref]

B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, B. E. Bouma, "Three dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging," Nat. Med. 15, 1219‒1223 (2009)
[Crossref]

Brophy, C. M.

C. M. Brophy, "The dynamic regulation of blood vessel caliber," J. Vasc. Surg. 31, 391‒395 (2000)
[Crossref]

Cha, J.

A. Y. Park, B. K. Seo, O. H. Woo, K. S. Jung, K. R. Cho, E. K. Park, S. H. Cha, J. Cha, "The utility of ultrasound superb microvascular imaging for evaluation of breast tumour vascularity: Comparison with colour and power Doppler imaging regarding diagnostic performance," Clin. Radiol. 73, 304‒311 (2018)
[Crossref]

Cha, S. H.

A. Y. Park, B. K. Seo, O. H. Woo, K. S. Jung, K. R. Cho, E. K. Park, S. H. Cha, J. Cha, "The utility of ultrasound superb microvascular imaging for evaluation of breast tumour vascularity: Comparison with colour and power Doppler imaging regarding diagnostic performance," Clin. Radiol. 73, 304‒311 (2018)
[Crossref]

Chen, C.-L.

Z. Chu, J. Lin, C. Gao, C. Xin, Q. Zhang, C.-L. Chen, L. Roisman, G. Gregori, P. J. Rosenfeld, R. K. Wang, "Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography," J. Biomed. Opt. 21, 066008 (2016)
[Crossref]

Chen, Z.

Cheng, L.

J. Pan, L. Cheng, X. Bi, X. Zhang, S. Liu, X. Bai, F. Li, A. Z. Zhao, "Elevation of ω-3 polyunsaturated fatty acids attenuates PTEN-deficiency induced endometrial cancer development through regulation of COX-2 and PGE2 production," Sci Rep 5, 1‒12 (2015)

Chico-Calero, I.

Cho, K. R.

A. Y. Park, B. K. Seo, O. H. Woo, K. S. Jung, K. R. Cho, E. K. Park, S. H. Cha, J. Cha, "The utility of ultrasound superb microvascular imaging for evaluation of breast tumour vascularity: Comparison with colour and power Doppler imaging regarding diagnostic performance," Clin. Radiol. 73, 304‒311 (2018)
[Crossref]

Choi, E.-S.

T. J. Eom, H. S. Kim, C. M. Kim, Y. L. Lee, E.-S. Choi, Real time display Fourier-domain OCT using multithread parallel computing with data vectorization .

Chu, Z.

Z. Chu, J. Lin, C. Gao, C. Xin, Q. Zhang, C.-L. Chen, L. Roisman, G. Gregori, P. J. Rosenfeld, R. K. Wang, "Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography," J. Biomed. Opt. 21, 066008 (2016)
[Crossref]

Crouch, B. T.

A. F. Martinez, S. S. M. Iii, M. Lee, H. A. Murphy, B. T. Crouch, H. L. Martin, A. Erkanli, N. Rajaram, K. A. Ashcraft, A. N. Fontanella, M. W. Dewhirst, N. Ramanujam, "Metaboloptics: visualization of the tumor functional landscape via metabolic and vascular imaging," Sci. Rep. 8, 1‒15 (2018)
[Crossref]

Dewhirst, M. W.

A. F. Martinez, S. S. M. Iii, M. Lee, H. A. Murphy, B. T. Crouch, H. L. Martin, A. Erkanli, N. Rajaram, K. A. Ashcraft, A. N. Fontanella, M. W. Dewhirst, N. Ramanujam, "Metaboloptics: visualization of the tumor functional landscape via metabolic and vascular imaging," Sci. Rep. 8, 1‒15 (2018)
[Crossref]

G. M. Palmer, A. N. Fontanella, S. Shan, G. Hanna, G. Zhang, C. L. Fraser, M. W. Dewhirst, "In vivo optical molecular imaging and analysis in mice using dorsal window chamber models applied to hypoxia vasculature and fluorescent reporters," Nat. Protoc. 6, 1355‒1366 (2011)
[Crossref]

Dhalla, A.

Diedenhofen, M.

R. T. Ullrich, J. F. Jikeli, M. Diedenhofen, P. Bo, M. Unruh, S. Vollmar, M. Hoehn, "In-vivo visualization of tumor microvessel density and response to anti-angiogenic treatment by high resolution MRI in Mice," PLoS One 6, e19592 (2011)
[Crossref]

Ding, Y.

J. Yang, C. Liao, Y. Liu, G. Yang, T. Ke, Y. Ding, L. Qinqing, "MR imaging biomarkers evaluating vascular normalization window after anti-vessel treatment," Oncotarget 9, 11964‒11976 (2018)

Eliceiri, K. W.

C. A. Schneider, W. S. Rasband, K. W. Eliceiri, "NIH Image to ImageJ: 25 years of image analysis," Nat. Methods 9, 671‒675 (2012)
[Crossref]

Eom, T. J.

M. G. Hyeon, H.-J. Kim, B.-M. Kim, T. J. Eom, "Spectral domain optical coherence tomography with balanced detection using single line-scan camera and optical delay line," Opt. Express 23, 23079‒23091 (2015)
[Crossref]

T. J. Eom, H. S. Kim, C. M. Kim, Y. L. Lee, E.-S. Choi, Real time display Fourier-domain OCT using multithread parallel computing with data vectorization .

H. S. Kim, S. Lee, K. Lee, T. J. Eom, J. G. Kim, Visualization of tumor vascular reactivity in response to respiratory challenges by optical coherence tomography (Conference Presentation) .

Era, S.

S. Tsutsui, M. Kume, S. Era, "Prognostic value of microvessel density in invasive ductal carcinoma of the breast," Breast Cancer 10, 312‒319 (2003)
[Crossref]

Erkanli, A.

A. F. Martinez, S. S. M. Iii, M. Lee, H. A. Murphy, B. T. Crouch, H. L. Martin, A. Erkanli, N. Rajaram, K. A. Ashcraft, A. N. Fontanella, M. W. Dewhirst, N. Ramanujam, "Metaboloptics: visualization of the tumor functional landscape via metabolic and vascular imaging," Sci. Rep. 8, 1‒15 (2018)
[Crossref]

Fontanella, A. N.

A. F. Martinez, S. S. M. Iii, M. Lee, H. A. Murphy, B. T. Crouch, H. L. Martin, A. Erkanli, N. Rajaram, K. A. Ashcraft, A. N. Fontanella, M. W. Dewhirst, N. Ramanujam, "Metaboloptics: visualization of the tumor functional landscape via metabolic and vascular imaging," Sci. Rep. 8, 1‒15 (2018)
[Crossref]

G. M. Palmer, A. N. Fontanella, S. Shan, G. Hanna, G. Zhang, C. L. Fraser, M. W. Dewhirst, "In vivo optical molecular imaging and analysis in mice using dorsal window chamber models applied to hypoxia vasculature and fluorescent reporters," Nat. Protoc. 6, 1355‒1366 (2011)
[Crossref]

Fraser, C. L.

G. M. Palmer, A. N. Fontanella, S. Shan, G. Hanna, G. Zhang, C. L. Fraser, M. W. Dewhirst, "In vivo optical molecular imaging and analysis in mice using dorsal window chamber models applied to hypoxia vasculature and fluorescent reporters," Nat. Protoc. 6, 1355‒1366 (2011)
[Crossref]

Fukumura, D.

B. J. Vakoc, D. Fukumura, R. K. Jain, B. E. Bouma, "Cancer imaging by optical coherence tomography: preclinical progress and clinical potential," Nat. Rev. Cancer 12, 363‒368 (2012)
[Crossref]

B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, B. E. Bouma, "Three dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging," Nat. Med. 15, 1219‒1223 (2009)
[Crossref]

Gao, C.

Z. Chu, J. Lin, C. Gao, C. Xin, Q. Zhang, C.-L. Chen, L. Roisman, G. Gregori, P. J. Rosenfeld, R. K. Wang, "Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography," J. Biomed. Opt. 21, 066008 (2016)
[Crossref]

Gazit, Y.

Y. Gazit, J. W. Baish, N. Safabakhsh, M. Leunig, L. T. Baxter, R. K. Jain, "Fractal characteristics of tumor vascular architecture during tumor growth and regression," Microcirculation 4, 395‒402 (1997)
[Crossref]

Y. Gazit, D. A. Berk, M. Leunig, L. T. Baxter, R. K. Jain, "Scale-invariant behavior and vascular network formation in normal and tumor tissue," Phys. Rev. Lett. 75, 2428‒2431 (1995)
[Crossref]

Ghaghada, K. B.

K. B. Ghaghada, Z. Starosolski, I. Stupin, P. Sarkar, A. Annapragada, Interrogation of evolving tumor vasculature using high-resolution CT imaging and a nanoparticle contrast agent .

Goetz, A. E.

M. Leunig, F. Yuan, M. D. Menger, Y. Boucher, A. E. Goetz, K. Messmer, R. K. Jain, "Angiogenesis microvascular architecture microhemodynamics and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice," Cancer Res. 52, 6553‒6560 (1992)

Gregori, G.

Z. Chu, J. Lin, C. Gao, C. Xin, Q. Zhang, C.-L. Chen, L. Roisman, G. Gregori, P. J. Rosenfeld, R. K. Wang, "Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography," J. Biomed. Opt. 21, 066008 (2016)
[Crossref]

Gundogdu, C.

E. Sener, S. Sipal, C. Gundogdu, "Comparison of microvessel density with prognostic factors in invasive ductal carcinomas of the breast," Turk Patoloji Derg. 32, 164‒170 (2016)

Hanna, G.

G. M. Palmer, A. N. Fontanella, S. Shan, G. Hanna, G. Zhang, C. L. Fraser, M. W. Dewhirst, "In vivo optical molecular imaging and analysis in mice using dorsal window chamber models applied to hypoxia vasculature and fluorescent reporters," Nat. Protoc. 6, 1355‒1366 (2011)
[Crossref]

Hoehn, M.

R. T. Ullrich, J. F. Jikeli, M. Diedenhofen, P. Bo, M. Unruh, S. Vollmar, M. Hoehn, "In-vivo visualization of tumor microvessel density and response to anti-angiogenic treatment by high resolution MRI in Mice," PLoS One 6, e19592 (2011)
[Crossref]

Hu, P.

L. Lin, P. Hu, J. Shi, K. I. Maslov, L. V. Wang, C. M. Appleton, Clinical photoacoustic computed tomography of the human breast in vivo within a single breath hold .

Huang, D.

Hyeon, M. G.

Iii, S. S. M.

A. F. Martinez, S. S. M. Iii, M. Lee, H. A. Murphy, B. T. Crouch, H. L. Martin, A. Erkanli, N. Rajaram, K. A. Ashcraft, A. N. Fontanella, M. W. Dewhirst, N. Ramanujam, "Metaboloptics: visualization of the tumor functional landscape via metabolic and vascular imaging," Sci. Rep. 8, 1‒15 (2018)
[Crossref]

Jain, R. K.

B. J. Vakoc, D. Fukumura, R. K. Jain, B. E. Bouma, "Cancer imaging by optical coherence tomography: preclinical progress and clinical potential," Nat. Rev. Cancer 12, 363‒368 (2012)
[Crossref]

B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, B. E. Bouma, "Three dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging," Nat. Med. 15, 1219‒1223 (2009)
[Crossref]

Y. Gazit, J. W. Baish, N. Safabakhsh, M. Leunig, L. T. Baxter, R. K. Jain, "Fractal characteristics of tumor vascular architecture during tumor growth and regression," Microcirculation 4, 395‒402 (1997)
[Crossref]

Y. Gazit, D. A. Berk, M. Leunig, L. T. Baxter, R. K. Jain, "Scale-invariant behavior and vascular network formation in normal and tumor tissue," Phys. Rev. Lett. 75, 2428‒2431 (1995)
[Crossref]

M. Leunig, F. Yuan, M. D. Menger, Y. Boucher, A. E. Goetz, K. Messmer, R. K. Jain, "Angiogenesis microvascular architecture microhemodynamics and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice," Cancer Res. 52, 6553‒6560 (1992)

Jarvi, M.

Jemal, A.

R. L. Siegel, K. D. Miller, A. Jemal, "Cancer statistics 2017," CA. Cancer J. Clin. 67, 7‒30 (2017)
[Crossref]

Jeong, H.

S. Lee, H. Jeong, M. Seong, J. G. Kim, "Change of tumor vascular reactivity during tumor growth and postchemotherapy observed by near-infrared spectroscopy," J. Biomed. Opt. 22, 121603 (2017)
[Crossref]

Jia, Y.

Jikeli, J. F.

R. T. Ullrich, J. F. Jikeli, M. Diedenhofen, P. Bo, M. Unruh, S. Vollmar, M. Hoehn, "In-vivo visualization of tumor microvessel density and response to anti-angiogenic treatment by high resolution MRI in Mice," PLoS One 6, e19592 (2011)
[Crossref]

Jung, K. S.

A. Y. Park, B. K. Seo, O. H. Woo, K. S. Jung, K. R. Cho, E. K. Park, S. H. Cha, J. Cha, "The utility of ultrasound superb microvascular imaging for evaluation of breast tumour vascularity: Comparison with colour and power Doppler imaging regarding diagnostic performance," Clin. Radiol. 73, 304‒311 (2018)
[Crossref]

Kamal, V.

J. N. Bharti, P. Rani, V. Kamal, P. N. Agarwal, "Angiogenesis in breast cancer and its correlation with estrogen progesterone receptors and other prognostic factors," J. Clin. Diagn. Res. 9, 5‒7 (2015)

Ke, T.

J. Yang, C. Liao, Y. Liu, G. Yang, T. Ke, Y. Ding, L. Qinqing, "MR imaging biomarkers evaluating vascular normalization window after anti-vessel treatment," Oncotarget 9, 11964‒11976 (2018)

Kim, B.-M.

Kim, C. M.

T. J. Eom, H. S. Kim, C. M. Kim, Y. L. Lee, E.-S. Choi, Real time display Fourier-domain OCT using multithread parallel computing with data vectorization .

Kim, H. S.

T. J. Eom, H. S. Kim, C. M. Kim, Y. L. Lee, E.-S. Choi, Real time display Fourier-domain OCT using multithread parallel computing with data vectorization .

H. S. Kim, S. Lee, K. Lee, T. J. Eom, J. G. Kim, Visualization of tumor vascular reactivity in response to respiratory challenges by optical coherence tomography (Conference Presentation) .

Kim, H.-J.

Kim, J. G.

S. Lee, H. Jeong, M. Seong, J. G. Kim, "Change of tumor vascular reactivity during tumor growth and postchemotherapy observed by near-infrared spectroscopy," J. Biomed. Opt. 22, 121603 (2017)
[Crossref]

H. S. Kim, S. Lee, K. Lee, T. J. Eom, J. G. Kim, Visualization of tumor vascular reactivity in response to respiratory challenges by optical coherence tomography (Conference Presentation) .

Kume, M.

S. Tsutsui, M. Kume, S. Era, "Prognostic value of microvessel density in invasive ductal carcinoma of the breast," Breast Cancer 10, 312‒319 (2003)
[Crossref]

Lanning, R. M.

B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, B. E. Bouma, "Three dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging," Nat. Med. 15, 1219‒1223 (2009)
[Crossref]

Lee, K.

A. Mariampillai, M. K. K. Leung, M. Jarvi, B. A. Standish, K. Lee, B. C. Wilson, A. Vitkin, V. X. D. Yang, "Optimized speckle variance OCT imaging of microvasculature," Opt. Lett. 35, 1257‒1259 (2010)
[Crossref]

H. S. Kim, S. Lee, K. Lee, T. J. Eom, J. G. Kim, Visualization of tumor vascular reactivity in response to respiratory challenges by optical coherence tomography (Conference Presentation) .

Lee, M.

A. F. Martinez, S. S. M. Iii, M. Lee, H. A. Murphy, B. T. Crouch, H. L. Martin, A. Erkanli, N. Rajaram, K. A. Ashcraft, A. N. Fontanella, M. W. Dewhirst, N. Ramanujam, "Metaboloptics: visualization of the tumor functional landscape via metabolic and vascular imaging," Sci. Rep. 8, 1‒15 (2018)
[Crossref]

Lee, S.

S. Lee, H. Jeong, M. Seong, J. G. Kim, "Change of tumor vascular reactivity during tumor growth and postchemotherapy observed by near-infrared spectroscopy," J. Biomed. Opt. 22, 121603 (2017)
[Crossref]

H. S. Kim, S. Lee, K. Lee, T. J. Eom, J. G. Kim, Visualization of tumor vascular reactivity in response to respiratory challenges by optical coherence tomography (Conference Presentation) .

Lee, Y. L.

T. J. Eom, H. S. Kim, C. M. Kim, Y. L. Lee, E.-S. Choi, Real time display Fourier-domain OCT using multithread parallel computing with data vectorization .

Leung, M. K. K.

Leunig, M.

Y. Gazit, J. W. Baish, N. Safabakhsh, M. Leunig, L. T. Baxter, R. K. Jain, "Fractal characteristics of tumor vascular architecture during tumor growth and regression," Microcirculation 4, 395‒402 (1997)
[Crossref]

Y. Gazit, D. A. Berk, M. Leunig, L. T. Baxter, R. K. Jain, "Scale-invariant behavior and vascular network formation in normal and tumor tissue," Phys. Rev. Lett. 75, 2428‒2431 (1995)
[Crossref]

M. Leunig, F. Yuan, M. D. Menger, Y. Boucher, A. E. Goetz, K. Messmer, R. K. Jain, "Angiogenesis microvascular architecture microhemodynamics and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice," Cancer Res. 52, 6553‒6560 (1992)

Li, F.

J. Pan, L. Cheng, X. Bi, X. Zhang, S. Liu, X. Bai, F. Li, A. Z. Zhao, "Elevation of ω-3 polyunsaturated fatty acids attenuates PTEN-deficiency induced endometrial cancer development through regulation of COX-2 and PGE2 production," Sci Rep 5, 1‒12 (2015)

Li, H.

Y. Li, H. Yu, L. Zhang, H. Li, "Effects of various vasoactive agents on tumor blood flow in rat," Chin. J. Cancer Res. 5, 116‒121 (1993)
[Crossref]

Li, Y.

Y. Li, H. Yu, L. Zhang, H. Li, "Effects of various vasoactive agents on tumor blood flow in rat," Chin. J. Cancer Res. 5, 116‒121 (1993)
[Crossref]

Liao, C.

J. Yang, C. Liao, Y. Liu, G. Yang, T. Ke, Y. Ding, L. Qinqing, "MR imaging biomarkers evaluating vascular normalization window after anti-vessel treatment," Oncotarget 9, 11964‒11976 (2018)

Lin, A. J.

Lin, J.

Z. Chu, J. Lin, C. Gao, C. Xin, Q. Zhang, C.-L. Chen, L. Roisman, G. Gregori, P. J. Rosenfeld, R. K. Wang, "Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography," J. Biomed. Opt. 21, 066008 (2016)
[Crossref]

Lin, L.

L. Lin, P. Hu, J. Shi, K. I. Maslov, L. V. Wang, C. M. Appleton, Clinical photoacoustic computed tomography of the human breast in vivo within a single breath hold .

Liu, G.

Liu, S.

J. Pan, L. Cheng, X. Bi, X. Zhang, S. Liu, X. Bai, F. Li, A. Z. Zhao, "Elevation of ω-3 polyunsaturated fatty acids attenuates PTEN-deficiency induced endometrial cancer development through regulation of COX-2 and PGE2 production," Sci Rep 5, 1‒12 (2015)

Liu, Y.

J. Yang, C. Liao, Y. Liu, G. Yang, T. Ke, Y. Ding, L. Qinqing, "MR imaging biomarkers evaluating vascular normalization window after anti-vessel treatment," Oncotarget 9, 11964‒11976 (2018)

Mariampillai, A.

Martin, H. L.

A. F. Martinez, S. S. M. Iii, M. Lee, H. A. Murphy, B. T. Crouch, H. L. Martin, A. Erkanli, N. Rajaram, K. A. Ashcraft, A. N. Fontanella, M. W. Dewhirst, N. Ramanujam, "Metaboloptics: visualization of the tumor functional landscape via metabolic and vascular imaging," Sci. Rep. 8, 1‒15 (2018)
[Crossref]

Martinez, A. F.

A. F. Martinez, S. S. M. Iii, M. Lee, H. A. Murphy, B. T. Crouch, H. L. Martin, A. Erkanli, N. Rajaram, K. A. Ashcraft, A. N. Fontanella, M. W. Dewhirst, N. Ramanujam, "Metaboloptics: visualization of the tumor functional landscape via metabolic and vascular imaging," Sci. Rep. 8, 1‒15 (2018)
[Crossref]

Maslov, K. I.

L. Lin, P. Hu, J. Shi, K. I. Maslov, L. V. Wang, C. M. Appleton, Clinical photoacoustic computed tomography of the human breast in vivo within a single breath hold .

Menger, M. D.

M. Leunig, F. Yuan, M. D. Menger, Y. Boucher, A. E. Goetz, K. Messmer, R. K. Jain, "Angiogenesis microvascular architecture microhemodynamics and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice," Cancer Res. 52, 6553‒6560 (1992)

Messmer, K.

M. Leunig, F. Yuan, M. D. Menger, Y. Boucher, A. E. Goetz, K. Messmer, R. K. Jain, "Angiogenesis microvascular architecture microhemodynamics and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice," Cancer Res. 52, 6553‒6560 (1992)

Miller, K. D.

R. L. Siegel, K. D. Miller, A. Jemal, "Cancer statistics 2017," CA. Cancer J. Clin. 67, 7‒30 (2017)
[Crossref]

Munn, L. L.

B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, B. E. Bouma, "Three dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging," Nat. Med. 15, 1219‒1223 (2009)
[Crossref]

Murphy, H. A.

A. F. Martinez, S. S. M. Iii, M. Lee, H. A. Murphy, B. T. Crouch, H. L. Martin, A. Erkanli, N. Rajaram, K. A. Ashcraft, A. N. Fontanella, M. W. Dewhirst, N. Ramanujam, "Metaboloptics: visualization of the tumor functional landscape via metabolic and vascular imaging," Sci. Rep. 8, 1‒15 (2018)
[Crossref]

Nam, A. S.

Padera, T. P.

B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, B. E. Bouma, "Three dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging," Nat. Med. 15, 1219‒1223 (2009)
[Crossref]

Palmer, G. M.

G. M. Palmer, A. N. Fontanella, S. Shan, G. Hanna, G. Zhang, C. L. Fraser, M. W. Dewhirst, "In vivo optical molecular imaging and analysis in mice using dorsal window chamber models applied to hypoxia vasculature and fluorescent reporters," Nat. Protoc. 6, 1355‒1366 (2011)
[Crossref]

Pan, J.

J. Pan, L. Cheng, X. Bi, X. Zhang, S. Liu, X. Bai, F. Li, A. Z. Zhao, "Elevation of ω-3 polyunsaturated fatty acids attenuates PTEN-deficiency induced endometrial cancer development through regulation of COX-2 and PGE2 production," Sci Rep 5, 1‒12 (2015)

Park, A. Y.

A. Y. Park, B. K. Seo, O. H. Woo, K. S. Jung, K. R. Cho, E. K. Park, S. H. Cha, J. Cha, "The utility of ultrasound superb microvascular imaging for evaluation of breast tumour vascularity: Comparison with colour and power Doppler imaging regarding diagnostic performance," Clin. Radiol. 73, 304‒311 (2018)
[Crossref]

Park, E. K.

A. Y. Park, B. K. Seo, O. H. Woo, K. S. Jung, K. R. Cho, E. K. Park, S. H. Cha, J. Cha, "The utility of ultrasound superb microvascular imaging for evaluation of breast tumour vascularity: Comparison with colour and power Doppler imaging regarding diagnostic performance," Clin. Radiol. 73, 304‒311 (2018)
[Crossref]

Qinqing, L.

J. Yang, C. Liao, Y. Liu, G. Yang, T. Ke, Y. Ding, L. Qinqing, "MR imaging biomarkers evaluating vascular normalization window after anti-vessel treatment," Oncotarget 9, 11964‒11976 (2018)

Rajaram, N.

A. F. Martinez, S. S. M. Iii, M. Lee, H. A. Murphy, B. T. Crouch, H. L. Martin, A. Erkanli, N. Rajaram, K. A. Ashcraft, A. N. Fontanella, M. W. Dewhirst, N. Ramanujam, "Metaboloptics: visualization of the tumor functional landscape via metabolic and vascular imaging," Sci. Rep. 8, 1‒15 (2018)
[Crossref]

Ramanujam, N.

A. F. Martinez, S. S. M. Iii, M. Lee, H. A. Murphy, B. T. Crouch, H. L. Martin, A. Erkanli, N. Rajaram, K. A. Ashcraft, A. N. Fontanella, M. W. Dewhirst, N. Ramanujam, "Metaboloptics: visualization of the tumor functional landscape via metabolic and vascular imaging," Sci. Rep. 8, 1‒15 (2018)
[Crossref]

Rani, P.

J. N. Bharti, P. Rani, V. Kamal, P. N. Agarwal, "Angiogenesis in breast cancer and its correlation with estrogen progesterone receptors and other prognostic factors," J. Clin. Diagn. Res. 9, 5‒7 (2015)

Rasband, W. S.

C. A. Schneider, W. S. Rasband, K. W. Eliceiri, "NIH Image to ImageJ: 25 years of image analysis," Nat. Methods 9, 671‒675 (2012)
[Crossref]

Roisman, L.

Z. Chu, J. Lin, C. Gao, C. Xin, Q. Zhang, C.-L. Chen, L. Roisman, G. Gregori, P. J. Rosenfeld, R. K. Wang, "Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography," J. Biomed. Opt. 21, 066008 (2016)
[Crossref]

Rosenfeld, P. J.

Z. Chu, J. Lin, C. Gao, C. Xin, Q. Zhang, C.-L. Chen, L. Roisman, G. Gregori, P. J. Rosenfeld, R. K. Wang, "Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography," J. Biomed. Opt. 21, 066008 (2016)
[Crossref]

Safabakhsh, N.

Y. Gazit, J. W. Baish, N. Safabakhsh, M. Leunig, L. T. Baxter, R. K. Jain, "Fractal characteristics of tumor vascular architecture during tumor growth and regression," Microcirculation 4, 395‒402 (1997)
[Crossref]

Sarkar, P.

K. B. Ghaghada, Z. Starosolski, I. Stupin, P. Sarkar, A. Annapragada, Interrogation of evolving tumor vasculature using high-resolution CT imaging and a nanoparticle contrast agent .

Schneider, C. A.

C. A. Schneider, W. S. Rasband, K. W. Eliceiri, "NIH Image to ImageJ: 25 years of image analysis," Nat. Methods 9, 671‒675 (2012)
[Crossref]

Sener, E.

E. Sener, S. Sipal, C. Gundogdu, "Comparison of microvessel density with prognostic factors in invasive ductal carcinomas of the breast," Turk Patoloji Derg. 32, 164‒170 (2016)

Seo, B. K.

A. Y. Park, B. K. Seo, O. H. Woo, K. S. Jung, K. R. Cho, E. K. Park, S. H. Cha, J. Cha, "The utility of ultrasound superb microvascular imaging for evaluation of breast tumour vascularity: Comparison with colour and power Doppler imaging regarding diagnostic performance," Clin. Radiol. 73, 304‒311 (2018)
[Crossref]

Seong, M.

S. Lee, H. Jeong, M. Seong, J. G. Kim, "Change of tumor vascular reactivity during tumor growth and postchemotherapy observed by near-infrared spectroscopy," J. Biomed. Opt. 22, 121603 (2017)
[Crossref]

Shan, S.

G. M. Palmer, A. N. Fontanella, S. Shan, G. Hanna, G. Zhang, C. L. Fraser, M. W. Dewhirst, "In vivo optical molecular imaging and analysis in mice using dorsal window chamber models applied to hypoxia vasculature and fluorescent reporters," Nat. Protoc. 6, 1355‒1366 (2011)
[Crossref]

Shi, J.

L. Lin, P. Hu, J. Shi, K. I. Maslov, L. V. Wang, C. M. Appleton, Clinical photoacoustic computed tomography of the human breast in vivo within a single breath hold .

Siegel, R. L.

R. L. Siegel, K. D. Miller, A. Jemal, "Cancer statistics 2017," CA. Cancer J. Clin. 67, 7‒30 (2017)
[Crossref]

Sipal, S.

E. Sener, S. Sipal, C. Gundogdu, "Comparison of microvessel density with prognostic factors in invasive ductal carcinomas of the breast," Turk Patoloji Derg. 32, 164‒170 (2016)

Standish, B. A.

Starosolski, Z.

K. B. Ghaghada, Z. Starosolski, I. Stupin, P. Sarkar, A. Annapragada, Interrogation of evolving tumor vasculature using high-resolution CT imaging and a nanoparticle contrast agent .

Stupin, I.

K. B. Ghaghada, Z. Starosolski, I. Stupin, P. Sarkar, A. Annapragada, Interrogation of evolving tumor vasculature using high-resolution CT imaging and a nanoparticle contrast agent .

Stylianopoulos, T.

B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, B. E. Bouma, "Three dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging," Nat. Med. 15, 1219‒1223 (2009)
[Crossref]

Tearney, G. J.

B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, B. E. Bouma, "Three dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging," Nat. Med. 15, 1219‒1223 (2009)
[Crossref]

Tokayer, J.

Tromberg, B. J.

Tsutsui, S.

S. Tsutsui, M. Kume, S. Era, "Prognostic value of microvessel density in invasive ductal carcinoma of the breast," Breast Cancer 10, 312‒319 (2003)
[Crossref]

Tyrrell, J. A.

B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, B. E. Bouma, "Three dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging," Nat. Med. 15, 1219‒1223 (2009)
[Crossref]

Ullrich, R. T.

R. T. Ullrich, J. F. Jikeli, M. Diedenhofen, P. Bo, M. Unruh, S. Vollmar, M. Hoehn, "In-vivo visualization of tumor microvessel density and response to anti-angiogenic treatment by high resolution MRI in Mice," PLoS One 6, e19592 (2011)
[Crossref]

Unruh, M.

R. T. Ullrich, J. F. Jikeli, M. Diedenhofen, P. Bo, M. Unruh, S. Vollmar, M. Hoehn, "In-vivo visualization of tumor microvessel density and response to anti-angiogenic treatment by high resolution MRI in Mice," PLoS One 6, e19592 (2011)
[Crossref]

Vakoc, B. J.

A. S. Nam, I. Chico-Calero, B. J. Vakoc, "Complex differential variance algorithm for optical coherence tomography angiography," Biomed. Opt. Express 5, 3822‒3832 (2014)
[Crossref]

B. J. Vakoc, D. Fukumura, R. K. Jain, B. E. Bouma, "Cancer imaging by optical coherence tomography: preclinical progress and clinical potential," Nat. Rev. Cancer 12, 363‒368 (2012)
[Crossref]

B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, B. E. Bouma, "Three dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging," Nat. Med. 15, 1219‒1223 (2009)
[Crossref]

Vitkin, A.

Vollmar, S.

R. T. Ullrich, J. F. Jikeli, M. Diedenhofen, P. Bo, M. Unruh, S. Vollmar, M. Hoehn, "In-vivo visualization of tumor microvessel density and response to anti-angiogenic treatment by high resolution MRI in Mice," PLoS One 6, e19592 (2011)
[Crossref]

Wang, L. V.

L. Lin, P. Hu, J. Shi, K. I. Maslov, L. V. Wang, C. M. Appleton, Clinical photoacoustic computed tomography of the human breast in vivo within a single breath hold .

Wang, R. K.

Z. Chu, J. Lin, C. Gao, C. Xin, Q. Zhang, C.-L. Chen, L. Roisman, G. Gregori, P. J. Rosenfeld, R. K. Wang, "Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography," J. Biomed. Opt. 21, 066008 (2016)
[Crossref]

S. Yousefi, R. K. Wang, "Simultaneous estimation of bidirectional particle flow and relative flux using MUSIC-OCT: phantom studies," Phys. Med. Biol. 59, 6693‒6708 (2014)
[Crossref]

Wilson, B. C.

Woo, O. H.

A. Y. Park, B. K. Seo, O. H. Woo, K. S. Jung, K. R. Cho, E. K. Park, S. H. Cha, J. Cha, "The utility of ultrasound superb microvascular imaging for evaluation of breast tumour vascularity: Comparison with colour and power Doppler imaging regarding diagnostic performance," Clin. Radiol. 73, 304‒311 (2018)
[Crossref]

Xin, C.

Z. Chu, J. Lin, C. Gao, C. Xin, Q. Zhang, C.-L. Chen, L. Roisman, G. Gregori, P. J. Rosenfeld, R. K. Wang, "Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography," J. Biomed. Opt. 21, 066008 (2016)
[Crossref]

Yang, G.

J. Yang, C. Liao, Y. Liu, G. Yang, T. Ke, Y. Ding, L. Qinqing, "MR imaging biomarkers evaluating vascular normalization window after anti-vessel treatment," Oncotarget 9, 11964‒11976 (2018)

Yang, J.

J. Yang, C. Liao, Y. Liu, G. Yang, T. Ke, Y. Ding, L. Qinqing, "MR imaging biomarkers evaluating vascular normalization window after anti-vessel treatment," Oncotarget 9, 11964‒11976 (2018)

Yang, V. X. D.

Yousefi, S.

S. Yousefi, R. K. Wang, "Simultaneous estimation of bidirectional particle flow and relative flux using MUSIC-OCT: phantom studies," Phys. Med. Biol. 59, 6693‒6708 (2014)
[Crossref]

Yu, H.

Y. Li, H. Yu, L. Zhang, H. Li, "Effects of various vasoactive agents on tumor blood flow in rat," Chin. J. Cancer Res. 5, 116‒121 (1993)
[Crossref]

Yuan, F.

M. Leunig, F. Yuan, M. D. Menger, Y. Boucher, A. E. Goetz, K. Messmer, R. K. Jain, "Angiogenesis microvascular architecture microhemodynamics and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice," Cancer Res. 52, 6553‒6560 (1992)

Zhang, G.

G. M. Palmer, A. N. Fontanella, S. Shan, G. Hanna, G. Zhang, C. L. Fraser, M. W. Dewhirst, "In vivo optical molecular imaging and analysis in mice using dorsal window chamber models applied to hypoxia vasculature and fluorescent reporters," Nat. Protoc. 6, 1355‒1366 (2011)
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Zhang, L.

Y. Li, H. Yu, L. Zhang, H. Li, "Effects of various vasoactive agents on tumor blood flow in rat," Chin. J. Cancer Res. 5, 116‒121 (1993)
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Zhang, Q.

Z. Chu, J. Lin, C. Gao, C. Xin, Q. Zhang, C.-L. Chen, L. Roisman, G. Gregori, P. J. Rosenfeld, R. K. Wang, "Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography," J. Biomed. Opt. 21, 066008 (2016)
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Zhang, X.

J. Pan, L. Cheng, X. Bi, X. Zhang, S. Liu, X. Bai, F. Li, A. Z. Zhao, "Elevation of ω-3 polyunsaturated fatty acids attenuates PTEN-deficiency induced endometrial cancer development through regulation of COX-2 and PGE2 production," Sci Rep 5, 1‒12 (2015)

Zhao, A. Z.

J. Pan, L. Cheng, X. Bi, X. Zhang, S. Liu, X. Bai, F. Li, A. Z. Zhao, "Elevation of ω-3 polyunsaturated fatty acids attenuates PTEN-deficiency induced endometrial cancer development through regulation of COX-2 and PGE2 production," Sci Rep 5, 1‒12 (2015)

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Breast Cancer (1)

S. Tsutsui, M. Kume, S. Era, "Prognostic value of microvessel density in invasive ductal carcinoma of the breast," Breast Cancer 10, 312‒319 (2003)
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R. L. Siegel, K. D. Miller, A. Jemal, "Cancer statistics 2017," CA. Cancer J. Clin. 67, 7‒30 (2017)
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M. Leunig, F. Yuan, M. D. Menger, Y. Boucher, A. E. Goetz, K. Messmer, R. K. Jain, "Angiogenesis microvascular architecture microhemodynamics and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice," Cancer Res. 52, 6553‒6560 (1992)

Chin. J. Cancer Res. (1)

Y. Li, H. Yu, L. Zhang, H. Li, "Effects of various vasoactive agents on tumor blood flow in rat," Chin. J. Cancer Res. 5, 116‒121 (1993)
[Crossref]

Clin. Radiol. (1)

A. Y. Park, B. K. Seo, O. H. Woo, K. S. Jung, K. R. Cho, E. K. Park, S. H. Cha, J. Cha, "The utility of ultrasound superb microvascular imaging for evaluation of breast tumour vascularity: Comparison with colour and power Doppler imaging regarding diagnostic performance," Clin. Radiol. 73, 304‒311 (2018)
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J. Biomed. Opt. (2)

Z. Chu, J. Lin, C. Gao, C. Xin, Q. Zhang, C.-L. Chen, L. Roisman, G. Gregori, P. J. Rosenfeld, R. K. Wang, "Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography," J. Biomed. Opt. 21, 066008 (2016)
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S. Lee, H. Jeong, M. Seong, J. G. Kim, "Change of tumor vascular reactivity during tumor growth and postchemotherapy observed by near-infrared spectroscopy," J. Biomed. Opt. 22, 121603 (2017)
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J. N. Bharti, P. Rani, V. Kamal, P. N. Agarwal, "Angiogenesis in breast cancer and its correlation with estrogen progesterone receptors and other prognostic factors," J. Clin. Diagn. Res. 9, 5‒7 (2015)

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C. M. Brophy, "The dynamic regulation of blood vessel caliber," J. Vasc. Surg. 31, 391‒395 (2000)
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Y. Gazit, J. W. Baish, N. Safabakhsh, M. Leunig, L. T. Baxter, R. K. Jain, "Fractal characteristics of tumor vascular architecture during tumor growth and regression," Microcirculation 4, 395‒402 (1997)
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Nat. Med. (1)

B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, B. E. Bouma, "Three dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging," Nat. Med. 15, 1219‒1223 (2009)
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Nat. Methods (1)

C. A. Schneider, W. S. Rasband, K. W. Eliceiri, "NIH Image to ImageJ: 25 years of image analysis," Nat. Methods 9, 671‒675 (2012)
[Crossref]

Nat. Protoc. (1)

G. M. Palmer, A. N. Fontanella, S. Shan, G. Hanna, G. Zhang, C. L. Fraser, M. W. Dewhirst, "In vivo optical molecular imaging and analysis in mice using dorsal window chamber models applied to hypoxia vasculature and fluorescent reporters," Nat. Protoc. 6, 1355‒1366 (2011)
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B. J. Vakoc, D. Fukumura, R. K. Jain, B. E. Bouma, "Cancer imaging by optical coherence tomography: preclinical progress and clinical potential," Nat. Rev. Cancer 12, 363‒368 (2012)
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J. Yang, C. Liao, Y. Liu, G. Yang, T. Ke, Y. Ding, L. Qinqing, "MR imaging biomarkers evaluating vascular normalization window after anti-vessel treatment," Oncotarget 9, 11964‒11976 (2018)

Opt. Express (1)

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S. Yousefi, R. K. Wang, "Simultaneous estimation of bidirectional particle flow and relative flux using MUSIC-OCT: phantom studies," Phys. Med. Biol. 59, 6693‒6708 (2014)
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Y. Gazit, D. A. Berk, M. Leunig, L. T. Baxter, R. K. Jain, "Scale-invariant behavior and vascular network formation in normal and tumor tissue," Phys. Rev. Lett. 75, 2428‒2431 (1995)
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R. T. Ullrich, J. F. Jikeli, M. Diedenhofen, P. Bo, M. Unruh, S. Vollmar, M. Hoehn, "In-vivo visualization of tumor microvessel density and response to anti-angiogenic treatment by high resolution MRI in Mice," PLoS One 6, e19592 (2011)
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Sci Rep (1)

J. Pan, L. Cheng, X. Bi, X. Zhang, S. Liu, X. Bai, F. Li, A. Z. Zhao, "Elevation of ω-3 polyunsaturated fatty acids attenuates PTEN-deficiency induced endometrial cancer development through regulation of COX-2 and PGE2 production," Sci Rep 5, 1‒12 (2015)

Sci. Rep. (1)

A. F. Martinez, S. S. M. Iii, M. Lee, H. A. Murphy, B. T. Crouch, H. L. Martin, A. Erkanli, N. Rajaram, K. A. Ashcraft, A. N. Fontanella, M. W. Dewhirst, N. Ramanujam, "Metaboloptics: visualization of the tumor functional landscape via metabolic and vascular imaging," Sci. Rep. 8, 1‒15 (2018)
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E. Sener, S. Sipal, C. Gundogdu, "Comparison of microvessel density with prognostic factors in invasive ductal carcinomas of the breast," Turk Patoloji Derg. 32, 164‒170 (2016)

Other (6)

K. B. Ghaghada, Z. Starosolski, I. Stupin, P. Sarkar, A. Annapragada, Interrogation of evolving tumor vasculature using high-resolution CT imaging and a nanoparticle contrast agent .

L. Lin, P. Hu, J. Shi, K. I. Maslov, L. V. Wang, C. M. Appleton, Clinical photoacoustic computed tomography of the human breast in vivo within a single breath hold .

ANSI Z136.1: American national standard for safe use of lasers .

T. J. Eom, H. S. Kim, C. M. Kim, Y. L. Lee, E.-S. Choi, Real time display Fourier-domain OCT using multithread parallel computing with data vectorization .

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H. S. Kim, S. Lee, K. Lee, T. J. Eom, J. G. Kim, Visualization of tumor vascular reactivity in response to respiratory challenges by optical coherence tomography (Conference Presentation) .

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