Abstract
Real-time high-throughput identification, screening, characterization, and
processing of biological specimen is of great interest to a host of areas
spanning from cell biology and medicine to security and defense. Much like
human biometrics, microorganisms exhibit natural signatures that can be used
for identification. In this paper, we first overview two optical techniques,
namely digital holographic microscopy and holographic optical tweezers which
can non-invasively image, manipulate, and identify microorganisms in three
dimensions. The two methods bear similarities in their optics and
implementation. Thus, we have proposed a new approach to identification of
micro/nano organisms and cells by combining the two methods of digital
holographic microscopy and holographic optical tweezers which can be
integrated into a single compact hardware. The proposed system can
simultaneously sense, control, identify, and track cells and microorganisms
in three dimensions. New possibilities that arise from the proposed method
are discussed.
© 2010 IEEE
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