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On-Off Interaction in the Human Electroretinogram

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Abstract

The “off” response of the human electroretinogram has been shown to resemble an inverted “on” response. The off response can only be obtained from a strongly light-adapted eye. The curve of response amplitude against length of stimulus flash passes through a maximum for flash durations of 12–20 msec, depending on the intensity of adaptation and stimulation. The curve of response amplitude against interval between two very short light flashes passes through a minimum for flash intervals of 15–25 msec under similar conditions of adaptation and stimulation. Algebraic addition of on and off responses or of two on responses has been shown to provide an adequate explanation of the two curves.

© 1961 Optical Society of America

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