Abstract

Optical diffraction tomography (ODT) is a label-free and noninvasive technique for biological imaging. However, ODT is only applicable to weakly scattering objects. To extend ODT to the multiple-scattering regime, more advanced inversion algorithms have been developed, including optimization-based ODT (Opti-ODT) and iterative ODT (iODT). In this paper, we propose a combined strategy, namely, an iODT initialization for Opti-ODT, based on the observed complementarity of their individual advantages. This study numerically demonstrates that under this combined strategy, the reconstruction can accurately converge to a better local minimum, especially in the case of multiply scattering objects with large optical path differences.

© 2021 Optical Society of America

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