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Two concepts for ultra-high-resolution polarization-sensitive optical coherence tomography with a single camera

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Abstract

Two designs with a multiplexed superluminescent diode for ultra-high-resolution spectral-domain polarization-sensitive optical coherence tomography (UHR-PS-OCT) are introduced. In the first design, a Wollaston prism separates orthogonal polarization states next to each other on one linescan camera; the other design uses a beam displacer to separate orthogonal states onto two lines of a linescan camera with multiple rows of detectors. The coherence lengths measured with the two systems were 3.6 µm and 2.9 µm ($n = {1.38}$), respectively. Measurements were collected from the fovea of a healthy subject, a healthy subject with astigmatism, and a patient with central serous retinopathy (CSR). A single volumetric scan provides double pass retardance induced by the retinal nerve fiber layer birefringence (RNFL) and its birefringence, the cumulative double pass retardance induced by the Henle fiber layer, and the retardance that is induced by the retinal pigment epithelium–Bruch’s membrane complex. The high axial resolution in UHR-PS-OCT is particularly helpful for the measurements of thin retinal tissue, such as the RNFL in the fovea, where birefringence values of around 1°/µm were found. Tilting of the retina due to a CSR or by off centering the imaging beam in the pupil causes an artificial increase in the double pass retardance induced by the RNFL and Henle fiber layer.

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Corrections

1 July 2022: A typographical correction was made to paragraph 6 of page 1306.


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Supplementary Material (3)

NameDescription
Visualization 1       Data set obtained from a healthy 30-year-old subject.
Visualization 2       Log-intensity B-scan of a healthy 30-year-old subject, similar to Fig. 5(a).
Visualization 3       15 deg by 15 deg wide data set obtained from a healthy 30-year-old subject showing the retardance induced by the RPE-BM complex.

Data availability

Data underlying the results presented in this paper are not publicly available at this time but may be obtained from the authors upon reasonable request.

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