Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group
Journal Home About Issues in Progress Current Issue All Issues Feature Issues

Complementary use of cross-polarization and standard OCT for differential diagnosis of pathological tissues

R. V. Kuranov, V. V. Sapozhnikova, I. V. Turchin, E. V. Zagainova, V. M. Gelikonov, V. A. Kamensky, L. B. Snopova, and N. N. Prodanetz

Open Access Open Access

Abstract

An experimental standard optical coherence tomography (OCT) setup that can be easily modified for cross-polarization OCT (CP OCT) operation has been developed to perform differential diagnosis of pathological tissues. The complementary use of CP OCT, a technique that provides a map of cross-polarization backscattering properties of an object being studied by means of low-coherence interferometry, and standard OCT imaging improves the specificity of diagnostics of pathological changes occurring in tissues. It is shown that healthy, neoplastic and scar tissues of the esophagus have different cross-polarization backscattering properties. A comparative analysis of CP OCT, OCT and histological images from one and the same tissue area has been made. A close correlation between the location of collagen fibers in biological tissue and signal intensity in CP OCT images is found.

©2001 Optical Society of America

Full Article  |  PDF Article
More Like This
Differential diagnosis of human bladder mucosa pathologies in vivo with cross-polarization optical coherence tomography

Elena Kiseleva, Mikhail Kirillin, Felix Feldchtein, Alex Vitkin, Ekaterina Sergeeva, Elena Zagaynova, Olga Streltzova, Boris Shakhov, Ekaterina Gubarkova, and Natalia Gladkova
Biomed. Opt. Express 6(4) 1464-1476 (2015)

Complementary use of polarization-sensitive and standard OCT metrics for enhanced intraoperative differentiation of breast cancer

Jianfeng Wang, Yang Xu, Kelly J. Mesa, Fredrick A. South, Eric J. Chaney, Darold R. Spillman, Ronit Barkalifa, Marina Marjanovic, P. Scott Carney, Anna M. Higham, Z. George Liu, and Stephen A. Boppart
Biomed. Opt. Express 9(12) 6519-6528 (2018)

Differentiation of ex vivo human breast tissue using polarization-sensitive optical coherence tomography

Fredrick A. South, Eric J. Chaney, Marina Marjanovic, Steven G. Adie, and Stephen A. Boppart
Biomed. Opt. Express 5(10) 3417-3426 (2014)

View More...

Cited By

Optica participates in Crossref's Cited-By Linking service. Citing articles from Optica Publishing Group journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (5)
Fig. 1.
Fig. 1. Standard OCT images printed in logarithmic scale of different diseases a) laryngitis (chronic inflammation of larynx) b) laryngeal cancer c) laryngeal papilloma. White bar corresponds to 1 mm.

Download Full Size | PDF

Fig.2
Fig.2 The experimental setup for the cross-polarization OCT. CS – crossectional scanner, O – investigated object, PS – longitudinal piezo-scanner, L – lenses, PD – photodiode, SA – selective amplifier, LA – logarithmic amplifier, AD – amplitude detector, ADC – analog to digital converter, PC – personal computer. Bold line corresponds to single-mode fiber, thin line - to polarization maintaining fiber.

Download Full Size | PDF

Fig. 3.
Fig. 3. a) Standard OCT image, b) CP OCT image c) H&E histology d), e) Van Gieson histology of healthy esophagus. White bar corresponds to 1 mm.

Download Full Size | PDF

Fig. 4.
Fig. 4. a) Standard OCT image, b) CP OCT image c) H&E histology d),e) Van Gieson histology of cancerous esophagus. White bar corresponds to 1 mm where not specially marked.

Download Full Size | PDF

Fig. 5.
Fig. 5. a) Standard OCT image, b) CP OCT image c) H&E histology d),e) Van Gieson histology of scar esophagus. White bar corresponds to 1 mm where not specially marked.

Download Full Size | PDF

Select as filters
Select Topics Cancel
Top
       
© Copyright 2024 | Optica Publishing Group. All rights reserved, including rights for text and data mining and training of artificial technologies or similar technologies.
Privacy | Terms of Use