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Intravascular photoacoustic imaging of human coronary atherosclerosis

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Abstract

We demonstrate intravascular photoacoustic imaging of human coronary atherosclerotic plaque. The data was obtained from two fresh human coronary arteries ex vivo, showing different stages of disease. A 1.25mm diameter intravascular imaging catheter was built, comprising an angle-polished optical fiber adjacent to a 30MHz ultrasound transducer. Specific photoacoustic imaging of lipid content, a key factor in vulnerable plaques that may lead to myocardial infarction, is achieved by spectroscopic imaging at different wavelengths between 1180 and 1230nm. Simultaneous imaging with intravascular ultrasound was performed.

© 2011 Optical Society of America

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