Imaging a full set of optical scattering properties of biological tissue by inverse spectroscopic optical coherence tomography

Ji Yi; Vadim Backman

doi:10.1364/OL.37.004443

Optics Letters
Vol. 37,
Issue 21,
pp. 4443-4445
(2012)
•https://doi.org/10.1364/OL.37.004443

Imaging a full set of optical scattering properties of biological tissue by inverse spectroscopic optical coherence tomography

Ji Yi and Vadim Backman

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Ji Yi and Vadim Backman, "Imaging a full set of optical scattering properties of biological tissue by inverse spectroscopic optical coherence tomography," Opt. Lett. 37, 4443-4445 (2012)

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Related Topics
Table of Contents Category
- Medical Optics and Biotechnology
Optics & Photonics Topics
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The topics in this list come from the Optics and Photonics Topics applied to this article.
Previously assigned OCIS codes
- Optical coherence tomography (170.4500)
- Inverse scattering (290.3200)
- Scattering measurements (290.5820)

About this Article
History
- Original Manuscript: June 13, 2012
- Revised Manuscript: September 20, 2012
- Manuscript Accepted: September 21, 2012
- Published: October 23, 2012
Virtual Issues
Virtual Journal for Biomedical Optics Vol. 7, Iss. 12

Abstract

We here develop a method to measure and image the full optical scattering properties by inverse spectroscopic optical coherence tomography (ISOCT). Tissue is modelled as a medium with continuous refractive index (RI) fluctuation and such a fluctuation is described by the RI correlation functions. Under the first-order Born approximation, the forward model is established for ISOCT. By measuring optical quantities of tissue including the scattering power of the OCT spectrum, the reflection albedo $α$ defined as the ratio of scattering coefficient $μ_{s}$ , and the backscattering coefficient $μ_{b}$ , we are able to inversely deduce the RI correlation function and image the full set of optical scattering properties.

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	$N$	$D$	$μ_{s}$ ( ${mm}^{- 1}$ )	$μ_{b}$ ( ${mm}^{- 1}$ )	$l_{c}$ (μm)a	$g$ a	$g$ from literature [1]
Brain	6	$2.80 \pm 0.21$	$10.81 \pm 0.28$	$0.65 \pm 0.08$	$0.76 \pm 0.29$	$0.87 \pm 0.05$	0.88 (633 nm)
Liver	10	$2.36 \pm 0.11$	$10.32 \pm 0.29$	$0.49 \pm 0.03$	$4.05 \pm 1.52$	$0.91 \pm 0.02$	0.95 (630 nm)
Lung (deflated)	9	$3.02 \pm 0.20$	$11.42 \pm 0.29$	$0.11 \pm 0.02$	$1.75 \pm 1.04$	$0.95 \pm 0.04$	0.95 (630 nm)
Heart	9	$2.84 \pm 0.08$	$13.26 \pm 0.37$	$0.27 \pm 0.06$	$2.59 \pm 0.96$	$0.96 \pm 0.02$	0.973–0.983 (1060 nm)
Intestine	7	$3.06 \pm 0.15$	$7.80 \pm 0.23$	$0.05 \pm 0.01$	$2.78 \pm 1.42$	$0.97 \pm 0.03$
Spleen	7	$2.98 \pm 0.19$	$13.28 \pm 0.30$	$0.26 \pm 0.09$	$1.71 \pm 1.13$	$0.95 \pm 0.03$

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