Abstract

We describe a novel frequency-domain photon migration instrument employing direct diode laser modulation and avalanche photodiode detection, which is capable of noninvasively determinating the optical properties of biological tissues in near real time. An infinite medium diffusion model was used to extract absorption and transport scattering coefficients from 300-kHz to 800-MHz photon-density wave phase data. Optical properties measured in tissue-simulating solutions at 670 nm agreed to within 10% of those expected.

© 1994 Optical Society of America

Frequency-domain photon migration measurements of normal and malignant tissue optical properties in a human subject

Joshua B. Fishkin, Olivier Coquoz, Eric R. Anderson, Matthew Brenner, and Bruce J. Tromberg
Appl. Opt. 36(1) 10-20 (1997)

Chemometric analysis of frequency-domain photon migration data: quantitative measurements of optical properties and chromophore concentrations in multicomponent turbid media

Andrew J. Berger, Vasan Venugopalan, Anthony J. Durkin, Tuan Pham, and Bruce J. Tromberg
Appl. Opt. 39(10) 1659-1667 (2000)

Optical property measurements of turbid media in a small-volume cuvette with frequency-domain photon migration

Olivier Coquoz, Lars O. Svaasand, and Bruce J. Tromberg
Appl. Opt. 40(34) 6281-6291 (2001)

Mathematical model for time-resolved and frequency-domain fluorescence spectroscopy in biological tissues

Michael S. Patterson and Brian W. Pogue
Appl. Opt. 33(10) 1963-1974 (1994)

Localization of absorbers in scattering media by use of frequency-domain measurements of time-dependent photon migration

E. M. Sevick, J. K. Frisoli, C. L. Burch, and J. R. Lakowicz
Appl. Opt. 33(16) 3562-3570 (1994)