Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Enhancing early bladder cancer detection with fluorescence-guided endoscopic optical coherent tomography

Not Accessible

Your library or personal account may give you access

Abstract

We report an experimental study of the possibility of enhancing early bladder cancer diagnosis with fluorescence-image-guided endoscopic optical coherence tomography (OCT). After the intravesical instillation of a 10% solution of 5-aminolevulinic acid, simultaneous fluorescence imaging (excitation of 380–420 nm, emission of 620–700 nm) and OCT are performed on rat bladders to identify the photochemical and morphological changes associated with uroepithelial tumorigenesis. The preliminary results of our ex vivo study reveal that both fluorescence and OCT can identify early uroepithelial cancers, and OCT can detect precancerous lesions (e.g., hyperplasia) that fluorescence may miss. This suggests that a cystoscope combining 5-aminolevulinic acid fluorescence and OCT imaging has the potential to enhance the efficiency and sensitivity of early bladder cancer diagnosis.

© 2003 Optical Society of America

Full Article  |  PDF Article
More Like This
Endoscopic optical coherence tomography with a modified microelectromechanical systems mirror for detection of bladder cancers

Tuqiang Xie, Huikai Xie, Gary K. Fedder, and Yingtian Pan
Appl. Opt. 42(31) 6422-6426 (2003)

Fluorescence-guided optical coherence tomography imaging for colon cancer screening: a preliminary mouse study

Nicusor Iftimia, Arun K. Iyer, Daniel X. Hammer, Niyom Lue, Mircea Mujat, Martha Pitman, R. Daniel Ferguson, and Mansoor Amiji
Biomed. Opt. Express 3(1) 178-191 (2012)

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (3)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved