Abstract

The phenomenon of enhanced backscattering (also known as coherent backscattering), an object of substantial scientific interest, has awaited application to tissue optics for the past two decades. Here we demonstrate, for the first time to our knowledge, depth-resolved spectroscopic elastic light scattering measurements in tissue by use of low-coherence enhanced backscattering (LEBS). We achieve the depth resolution by exploiting the nature of the LEBS peak that contains information about a wide range of tissue depths. We further demonstrate that depth-resolved LEBS spectroscopy has the potential to identify the origin of precancerous transformations in the colon at an early, previously undetectable stage.

© 2005 Optical Society of America

Low-coherent backscattering spectroscopy for tissue characterization

Young L. Kim, Yang Liu, Ramesh K. Wali, Hemant K. Roy, and Vadim Backman
Appl. Opt. 44(3) 366-377 (2005)

Depth-resolved measurement of mucosal microvascular blood content using 
low-coherence enhanced backscattering spectroscopy

Andrew J. Radosevich, Vladimir M. Turzhitsky, Nikhil N. Mutyal, Jeremy D. Rogers, Valentina Stoyneva, Ashish Kumar Tiwari, Mart De La Cruz, Dhananjay P. Kunte, Ramesh K. Wali, Hemant K. Roy, and Vadim Backman
Biomed. Opt. Express 1(4) 1196-1208 (2010)

A fiber optic probe design to measure depth- limited optical properties in-vivo with Low-coherence Enhanced Backscattering (LEBS) Spectroscopy

Nikhil N. Mutyal, Andrew Radosevich, Bradley Gould, Jeremy D. Rogers, Andrew Gomes, Vladimir Turzhitsky, and Vadim Backman
Opt. Express 20(18) 19643-19657 (2012)

Origin of low-coherence enhanced backscattering

Young L. Kim, Prabhakar Pradhan, Hariharan Subramanian, Yang Liu, Min H. Kim, and Vadim Backman
Opt. Lett. 31(10) 1459-1461 (2006)

Coherent backscattering spectroscopy

Young L. Kim, Yang Liu, Vladimir M. Turzhitsky, Hemant K. Roy, Ramesh K. Wali, and Vadim Backman
Opt. Lett. 29(16) 1906-1908 (2004)