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In vivo three-dimensional photoacoustic tomography of a whole mouse head

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Abstract

An in vivo photoacoustic imaging system was designed and implemented to image the entire small animal head. A special scanning gantry was designed to enable in vivo imaging in coronal cross sections with high contrast and good spatial resolution for the first time to our knowledge. By use of a 2.25MHz ultrasonic transducer with a 6mm diameter active element, an in-plane radial resolution of 312μm was achieved. Deeply seated arterial and venous vessels in the head measuring up to 1.7cm in diameter were simultaneously imaged in vivo with 804nm wavelength laser excitation of photoacoustic waves.

© 2006 Optical Society of America

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