Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Scattering differentiates Alzheimer disease in vitro

Not Accessible

Your library or personal account may give you access

Abstract

The molecular bases of Alzheimer disease and related neurodegenerative disorders are becoming better understood, but the means for definitive diagnosis and monitoring in vivo remain lacking. Near-infrared optical spectroscopy offers a potential solution. We acquired transmission and reflectance spectra of thin brain tissue slabs, from which we calculated wavelength-dependent absorption and reduced scattering coefficients from 4701000nm. The reduced scattering coefficients in the near infrared clearly differentiated Alzheimer from control specimens. Diffuse reflectance spectra of gross brain tissue in vitro confirmed this observation. These results suggest a means for diagnosing and monitoring Alzheimer disease in vivo, using near-infrared optical spectroscopy.

© 2008 Optical Society of America

Full Article  |  PDF Article
More Like This
Raman signature from brain hippocampus could aid Alzheimer's disease diagnosis

Pu Chen, Aiguo Shen, Wei Zhao, Seong-Joon Baek, Hua Yuan, and Jiming Hu
Appl. Opt. 48(24) 4743-4748 (2009)

Decoherence of photon entanglement by transmission through brain tissue with Alzheimer’s disease

E. J. Galvez, B. Sharma, F. K. Williams, C.-J. You, B. Khajavi, J. Castrillon, L. Shi, S. Mamani, L. A. Sordillo, L. Zhang, and R. R. Alfano
Biomed. Opt. Express 13(12) 6621-6630 (2022)

Evaluating β-amyloidosis progression in Alzheimer’s disease with Mueller polarimetry

Mariia Borovkova, Alexander Bykov, Alexey Popov, Angelo Pierangelo, Tatiana Novikova, Jens Pahnke, and Igor Meglinski
Biomed. Opt. Express 11(8) 4509-4519 (2020)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (4)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Equations (4)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Metrics

Select as filters


Select Topics Cancel
© Copyright 2022 | Optica Publishing Group. All Rights Reserved