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Label-free optical biosensing with slot-waveguides

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Abstract

We demonstrate label-free molecule detection by using an integrated biosensor based on a Si3N4SiO2 slot-waveguide microring resonator. Bovine serum albumin (BSA) and anti-BSA molecular binding events on the sensor surface are monitored through the measurement of resonant wavelength shifts with varying biomolecule concentrations. The biosensor exhibited sensitivities of 1.8 and 3.2nm(ngmm2) for the detection of anti-BSA and BSA, respectively. The estimated detection limits are 28 and 16pgmm2 for anti-BSA and BSA, respectively, limited by wavelength resolution.

© 2008 Optical Society of America

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