Abstract

We report experimental evidence and correction of defocus in full-field optical coherence tomography of biological samples owing to mismatch of the refractive index of biological tissues and water. Via a metric based on the image quality, we demonstrate that we are able to compensate this index-induced defocus and to recover a sharp image in depth.

© 2009 Optical Society of America

Brain refractive index measured in vivo with high-NA defocus-corrected full-field OCT and consequences for two-photon microscopy

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