Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Resonant four-wave mixing of gold nanoparticles for three-dimensional cell microscopy

Not Accessible

Your library or personal account may give you access

Abstract

By detecting the transient four-wave mixing from gold nanoparticles in resonance with their surface plasmon, we demonstrate a multiphoton imaging modality suited for cell microscopy. Four-wave mixing is measured free from background using a three-beam excitation geometry and heterodyne detection. We achieve a spatial resolution of 140nm in-plane and 470nm in the axial direction, surpassing the one-photon diffraction limit. With this technique, high-contrast photostable imaging of Golgi structures is demonstrated in HepG2 cells labeled with gold nanoparticles of 10nm and 5nm diameter.

© 2009 Optical Society of America

Full Article  |  PDF Article
More Like This
Imaging the uptake of gold nanoshells in live cells using plasmon resonance enhanced four wave mixing microscopy

Natalie Garrett, Matt Whiteman, and Julian Moger
Opt. Express 19(18) 17563-17574 (2011)

Raman Microscopy based on Doubly-Resonant Four-Wave Mixing (DR-FWM)

Tyler Weeks, Sebastian Wachsmann-Hogiu, and Thomas Huser
Opt. Express 17(19) 17044-17051 (2009)

Fast three-dimensional imaging of gold nanoparticles in living cells with photothermal optical lock-in Optical Coherence Microscopy

Christophe Pache, Noelia L. Bocchio, Arno Bouwens, Martin Villiger, Corinne Berclaz, Joan Goulley, Matthew I. Gibson, Christian Santschi, and Theo Lasser
Opt. Express 20(19) 21385-21399 (2012)

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (3)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved