Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Supercontinuum light source enables in vivo optical microangiography of capillary vessels within tissue beds

Not Accessible

Your library or personal account may give you access

Abstract

This Letter reports on the use of a supercontinuum light source to achieve ultrahigh resolution and ultrahigh sensitive optical microangiography (OMAG) imaging of microcirculations within tissue beds in vivo. After passing through a specially designed optical filter with a passband of 120nm centered on 800nm, the light source is coupled into an optic-fiber-based OMAG system that provides a measured axial resolution of 3μm over a ranging distance of 2mm. Within this ranging distance, the system gives an averaged signal-to-noise ratio of 87dB and a sensitivity roll-off of 7dB at an A-scan rate of 70kHz. We demonstrate the capability of the system to visualize a detailed microvascular perfusion map, including the single red blood cells within the capillaries, by imaging a mouse ear flap in vivo.

© 2011 Optical Society of America

Full Article  |  PDF Article
More Like This
Label-free 3D imaging of microstructure, blood, and lymphatic vessels within tissue beds in vivo

Zhongwei Zhi, Yeongri Jung, and Ruikang K. Wang
Opt. Lett. 37(5) 812-814 (2012)

Super-resolution spectral estimation of optical micro-angiography for quantifying blood flow within microcirculatory tissue beds in vivo

Siavash Yousefi, Jia Qin, and Ruikang K. Wang
Biomed. Opt. Express 4(7) 1214-1228 (2013)

Full range complex ultrahigh sensitive optical microangiography

Lin An and Ruikang K. Wang
Opt. Lett. 36(6) 831-833 (2011)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (3)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Metrics

Select as filters


Select Topics Cancel
© Copyright 2022 | Optica Publishing Group. All Rights Reserved