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High-sensitivity optical biosensor based on cascaded Mach–Zehnder interferometer and ring resonator using Vernier effect

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Abstract

We demonstrate an ultrahigh sensitivity silicon photonic biosensor based on cascaded Mach–Zehnder interferometer (MZI) and ring resonator with the Vernier effect using wavelength interrogation. Experimental results show that the sensitivities reached 2870 nm/RIU and 21,500 nm/RIU for MZI sensor and MZI-ring sensor, respectively. A biosensing application was demonstrated by monitoring the interaction between goat and antigoat immunoglobulin G (IgG) pairs. The measured results show that 1 ng/ml IgG resulted in 0.035 nm and 0.5 nm wavelength shift for MZI sensor and MZI-ring sensor, respectively. This high performance sensor is promising for medical diagnostic applications.

© 2014 Optical Society of America

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