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High-throughput optofluidic particle profiling with morphological and chemical specificity

Masashi Ugawa, Cheng Lei, Taisuke Nozawa, Takuro Ideguchi, Dino Di Carlo, Sadao Ota, Yasuyuki Ozeki, and Keisuke Goda

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Abstract

We present a method for high-throughput optofluidic particle analysis that provides both the morphological and chemical profiles of individual particles in a large heterogeneous population. This method is based on an integration of a time-stretch optical microscope with a submicrometer spatial resolution of 780 nm and a three-color fluorescence analyzer on top of an inertial-focusing microfluidic device. The integrated system can perform image- and fluorescence-based screening of particles with a high throughput of 10,000 particles/s, exceeding previously demonstrated imaging particle analyzers in terms of specificity without sacrificing throughput.

© 2015 Optical Society of America

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