Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Ultrahigh-resolution optical coherence elastography

Not Accessible

Your library or personal account may give you access

Abstract

Visualizing stiffness within the local tissue environment at the cellular and subcellular level promises to provide insight into the genesis and progression of disease. In this Letter, we propose ultrahigh-resolution optical coherence elastography (UHROCE), and demonstrate 3D imaging of local axial strain of tissues undergoing compressive loading. We combine optical coherence microscopy (OCM) and phase-sensitive detection of local tissue displacement to produce strain elastograms with resolution (x,y,z) of 2×2×15μm. We demonstrate this performance on a freshly excised mouse aorta and reveal the mechanical heterogeneity of vascular smooth muscle cells and elastin sheets, otherwise unresolved in a typical, lower resolution optical coherence elastography (OCE) system.

© 2015 Optical Society of America

Full Article  |  PDF Article
More Like This
Ultrahigh-resolution optical coherence elastography through a micro-endoscope: towards in vivo imaging of cellular-scale mechanics

Qi Fang, Andrea Curatolo, Philip Wijesinghe, Yen Ling Yeow, Juliana Hamzah, Peter B. Noble, Karol Karnowski, David D. Sampson, Ruth Ganss, Jun Ki Kim, Woei M. Lee, and Brendan F. Kennedy
Biomed. Opt. Express 8(11) 5127-5138 (2017)

Depth-encoded optical coherence elastography for simultaneous volumetric imaging of two tissue faces

Qi Fang, Luke Frewer, Philip Wijesinghe, Wes M. Allen, Lixin Chin, Juliana Hamzah, David D. Sampson, Andrea Curatolo, and Brendan F. Kennedy
Opt. Lett. 42(7) 1233-1236 (2017)

Crawling wave optical coherence elastography

Panomsak Meemon, Jianing Yao, Ying-Ju Chu, Fernando Zvietcovich, Kevin J. Parker, and Jannick P. Rolland
Opt. Lett. 41(5) 847-850 (2016)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (3)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Metrics

Select as filters


Select Topics Cancel
© Copyright 2022 | Optica Publishing Group. All Rights Reserved