Abstract

We report on the development of a unique sideview handheld hybrid Raman spectroscopy (RS) and optical coherence tomography (OCT) technique for real-time in vivo tissue measurements. A sideview handheld RS-OCT optical probe is designed to coalign the optical paths of RS and OCT sampling arms, whereby a compact long-pass dichroic mirror (LPDM) is utilized to transmit the OCT signal through a gradient index rod lens and a reflection mirror, whereas the LPDM deflects the tissue Raman signal by 90°, leading to coaligned RS/OCT optical samplings on the tissue. Further study shows that the hybrid RS and OCT technique developed is capable of simultaneously acquiring both morphological and biochemical information about the oral tissue in vivo, facilitating real-time, in vivo tissue diagnoses and characterizations in the oral cavity.

© 2016 Optical Society of America

Development of a coaxial DCF-GRIN fiberoptic Raman probe for enhancing in vivo epithelial tissue Raman measurements

Howard Peng Sin Heng, Chi Shu, Wei Zheng, and Zhiwei Huang
Opt. Lett. 47(22) 5989-5992 (2022)

Development and characterization of a disposable submillimeter fiber optic Raman needle probe for enhancing real-time in vivo deep tissue and biofluids Raman measurements

Chi Shu, Wei Zheng, Zhuo Wang, Changyuan Yu, and Zhiwei Huang
Opt. Lett. 46(20) 5197-5200 (2021)

Development of an intraoral handheld optical coherence tomography-based angiography probe for multi-site oral imaging

Tianyu Zhang, Simon Shepherd, Zhihong Huang, Michaelina Macluskey, and Chunhui Li
Opt. Lett. 48(18) 4857-4860 (2023)

Noninvasive in vivo structural and vascular imaging of human oral tissues with spectral domain optical coherence tomography

Bahar Davoudi, Andras Lindenmaier, Beau A. Standish, Ghassan Allo, Kostadinka Bizheva, and Alex Vitkin
Biomed. Opt. Express 3(5) 826-839 (2012)

Development of a multi-needle fiberoptic Raman spectroscopy technique for simultaneous multi-site deep tissue Raman measurements in the brain

Bocheng Qiu, Chi Shu, and Zhiwei Huang
Opt. Lett. 48(16) 4396-4399 (2023)