Pushing phase and amplitude sensitivity limits in interferometric microscopy

Poorya Hosseini; Renjie Zhou; Yang-Hyo Kim; Chiara Peres; Alberto Diaspro; Cuifang Kuang; Zahid Yaqoob; Peter T. C. So

doi:10.1364/OL.41.001656

Optics Letters
Vol. 41,
Issue 7,
pp. 1656-1659
(2016)
•https://doi.org/10.1364/OL.41.001656

Pushing phase and amplitude sensitivity limits in interferometric microscopy

Poorya Hosseini, Renjie Zhou, Yang-Hyo Kim, Chiara Peres, Alberto Diaspro, Cuifang Kuang, Zahid Yaqoob, and Peter T. C. So

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Poorya Hosseini, Renjie Zhou, Yang-Hyo Kim, Chiara Peres, Alberto Diaspro, Cuifang Kuang, Zahid Yaqoob, and Peter T. C. So, "Pushing phase and amplitude sensitivity limits in interferometric microscopy," Opt. Lett. 41, 1656-1659 (2016)

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- Instrumentation, Measurement, and Metrology
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About this Article
History
- Original Manuscript: January 22, 2016
- Revised Manuscript: February 26, 2016
- Manuscript Accepted: March 4, 2016
- Published: April 1, 2016
Virtual Issues
Virtual Journal for Biomedical Optics Vol. 11, Iss. 5

Abstract

Sensitivity of the amplitude and phase measurements in interferometric microscopy is influenced by factors such as instrument design and environmental interferences. Through development of a theoretical framework followed by experimental validation, we show photon shot noise is often the limiting factor in interferometric microscopy measurements. Thereafter, we demonstrate how a state-of-the-art camera with million-level electrons full well capacity can significantly reduce shot noise contribution resulting in a stability of optical path length down to a few picometers even in a near-common-path interferometer.

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	Photron		Adimec
	phase (rad)	amplitude	phase (rad)	amplitude
1 frame	$3.3 \times 10^{- 3}$	$3.3 \times 10^{- 3}$	$5.9 \times 10^{- 4}$	$5.9 \times 10^{- 4}$
10 frame	$1.1 \times 10^{- 3}$	$1.0 \times 10^{- 3}$	$19.1 \times 10^{- 4}$	$18.7 \times 10^{- 4}$
100 frame	$3.4 \times 10^{- 4}$	$3.3 \times 10^{- 4}$	$8.3 \times 10^{- 5}$	$7.2 \times 10^{- 5}$

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Optics Letters