Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of cilia

Not Accessible

Your library or personal account may give you access

Abstract

We report the design and fabrication of a flexible, longitudinally scanning high-resolution micro-optical coherence tomography (μOCT) endobronchial probe, optimized for micro-anatomical imaging in airways. The 2.4 mm diameter and flexibility of the probe allows it to be inserted into the instrument channel of a standard bronchoscope, enabling real-time video guidance of probe placement. To generate a depth-of-focus enhancing annular beam, we utilized a new fabrication method, whereby a hollow glass ferrule was angle-polished and gold-coated to produce an elongated annular reflector. We present validation data that verifies the preservation of linear scanning, despite the use of flexible materials. When utilized on excised, cultured mouse trachea, the probe acquired images of comparable quality to those obtained by a benchtop μOCT system.

© 2017 Optical Society of America

Full Article  |  PDF Article
More Like This
In vivo imaging of airway cilia and mucus clearance with micro-optical coherence tomography

Kengyeh K. Chu, Carolin Unglert, Tim N. Ford, Dongyao Cui, Robert W. Carruth, Kanwarpal Singh, Linbo Liu, Susan E. Birket, George M. Solomon, Steven M. Rowe, and Guillermo J. Tearney
Biomed. Opt. Express 7(7) 2494-2505 (2016)

Endoscopic micro-optical coherence tomography with extended depth of focus using a binary phase spatial filter

Junyoung Kim, Jingchao Xing, Hyeong Soo Nam, Joon Woo Song, Jin Won Kim, and Hongki Yoo
Opt. Lett. 42(3) 379-382 (2017)

Airway compliance measured by anatomic optical coherence tomography

Ruofei Bu, Santosh Balakrishnan, Nicusor Iftimia, Hillel Price, Carlton Zdanski, and Amy L. Oldenburg
Biomed. Opt. Express 8(4) 2195-2209 (2017)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Supplementary Material (1)

NameDescription
Visualization 1: AVI (8416 KB)      µOCT video of excised mouse trachea, acquired with the probe, demonstrating beating cilia.

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (5)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Metrics

Select as filters


Select Topics Cancel
© Copyright 2022 | Optica Publishing Group. All Rights Reserved