Abstract

We demonstrate a novel hybrid-beam scanning-based quantitative optical coherence tomography angiography (OCTA) that provides high-speed wide dynamic range blood flow speed imaging. The hybrid-beam scanning scheme enables multiple OCTA image acquisitions with a wide range of multiple time intervals simultaneously providing wide dynamic range blood flow speed imaging independent of the blood vessel orientation, which was quantified over a speed range of $0.6\sim 104\mathrm{mm}/\mathrm{s}$ through the blood flow phantom experiments. A fully automated high-speed hybrid-beam scanning-based quantitative OCTA system demonstrates visualization of blood flow speeds in various vessels from the main arteries to capillaries in a $4\mathrm{mm}\times 4\mathrm{mm}$ area (1024 A-lines × 512 B-scans) in vivo in 20 s, showing its potential as a useful imaging tool for various biomedical applications.

© 2018 Optical Society of America

Wide-field optical coherence tomography angiography enabled by two repeated measurements of B-scans

Ruikang K. Wang, Anqi Zhang, Woo June Choi, Qinqin Zhang, Chieh-li Chen, Andrew Miller, Giovanni Gregori, and Philip J. Rosenfeld
Opt. Lett. 41(10) 2330-2333 (2016)

Real-time cross-sectional and en face OCT angiography guiding high-quality scan acquisition

Xiang Wei, Acner Camino, Shaohua Pi, Tristan T. Hormel, William Cepurna, David Huang, John C. Morrison, and Yali Jia
Opt. Lett. 44(6) 1431-1434 (2019)

High dynamic range optical coherence tomography angiography (HDR-OCTA)

Xiang Wei, Tristan T. Hormel, Shaohua Pi, Yukun Guo, Yifan Jian, and Yali Jia
Biomed. Opt. Express 10(7) 3560-3571 (2019)

Universal digital filtering for denoising volumetric retinal OCT and OCT angiography in 3D shearlet domain

Jianlong Yang, Yan Hu, Liyang Fang, Jun Cheng, and Jiang Liu
Opt. Lett. 45(3) 694-697 (2020)

Optical coherence tomography based angiography [Invited]

Chieh-Li Chen and Ruikang K. Wang
Biomed. Opt. Express 8(2) 1056-1082 (2017)