Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Focused anti-scatter grid for background reduction in x-ray fluorescence tomography

Not Accessible

Your library or personal account may give you access

Abstract

X-ray fluorescence (XRF) tomography is an emerging imaging technology with the potential for high spatial resolution molecular imaging. One of the key limitations is the background noise due to Compton scattering since it degrades the signal and limits the sensitivity. In this Letter, we present a linear focused anti-scatter grid that reduces the Compton scattering background. An anti-scatter grid was manufactured and evaluated both experimentally and theoretically with Monte Carlo simulations. The measurements showed a 31% increase in signal-to-background ratio, and simulations of an improved grid showed that this can easily be extended up to >75%. Simulated tomographies using the improved grid show a large improvement in reconstruction quality. The anti-scatter grid will be important for in vivo XRF tomography since the background reduction allows for faster scan times, lower doses, and lower nanoparticle concentrations.

© 2018 Optical Society of America

Full Article  |  PDF Article
More Like This
Laboratory x-ray fluorescence tomography for high-resolution nanoparticle bio-imaging

Hans M. Hertz, Jakob C. Larsson, Ulf Lundström, Daniel H. Larsson, and Carmen Vogt
Opt. Lett. 39(9) 2790-2793 (2014)

Quantitative predictions in small-animal X-ray fluorescence tomography

Kian Shaker, Jakob C. Larsson, and Hans M. Hertz
Biomed. Opt. Express 10(8) 3773-3788 (2019)

High-sensitivity imaging and quantification of intratumoral distributions of gold nanoparticles using a benchtop x-ray fluorescence imaging system

Nivedh Manohar, Francisco Reynoso, Sandun Jayarathna, Hem Moktan, Md. Foiez Ahmed, Parmeswaran Diagaradjane, Sunil Krishnan, and Sang Hyun Cho
Opt. Lett. 44(21) 5314-5317 (2019)

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Figures (3)

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Equations (2)

You do not have subscription access to this journal. Equations are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Metrics

Select as filters


Select Topics Cancel
© Copyright 2022 | Optica Publishing Group. All Rights Reserved