Abstract

We demonstrate a real-time surface plasmon resonance imaging (SPRi) system based on a wavelength-swept laser. Compared to conventional spectral-modulation SPRi using white light source and spectral filtering, the proposed system has a higher scan rate to detect rapid changes in refractive index and a higher output power for large-area illumination. This SPRi system achieves scan rates faster than 12 Hz, simultaneously obtaining SPR dip positions over full illumination fields of $12\times 12\mathrm{mm}$. Using the wavelength-swept laser, two-dimensional biomolecular array imaging can be acquired with a high dynamic detection range ($7.67\times {10}^{-3}$ refractive index unit (RIU)) as well as high sensitivity (6501 nm/RIU) and resolution ($1.89\times {10}^{-6}\mathrm{RIU}$).

© 2018 Optical Society of America

Spectrometer-based wavelength interrogation SPR imaging via Hadamard transform

Soocheol Kim, Jin Hwa Ryu, Hoesung Yang, Kyuwon Han, Hyunseok Kim, Kwangsoo Cho, Soyoung Park, Sang Gi Hong, and Kangbok Lee
Opt. Lett. 48(4) 992-995 (2023)

Real-time multi-channel SPR sensing based on DMD-enabled angular interrogation

Dongping Wang, Fong-Chuen Loo, Hengji Cong, Wei Lin, Siu Kai Kong, Yeung Yam, Shih-Chi Chen, and Ho Pui Ho
Opt. Express 26(19) 24627-24636 (2018)

Multi-channel surface plasmon resonance biosensor using prism-based wavelength interrogation

Jieyao Li, Dandan Han, Junyi Zeng, Jinan Deng, Ning Hu, and Jun Yang
Opt. Express 28(9) 14007-14017 (2020)

Wavelength-multiplexing phase-sensitive surface plasmon imaging sensor

Yonghong Shao, Yan Li, Dayong Gu, Kai Zhang, Junle Qu, Jianan He, Xuejin Li, Shu-Yuen Wu, Ho-Pui Ho, Michael G. Somekh, and Hanben Niu
Opt. Lett. 38(9) 1370-1372 (2013)

Real-time standoff detection of nitrogen isotopes in ammonia plumes using a swept external cavity quantum cascade laser

Mark C. Phillips, Brian E. Brumfield, and Sivanandan S. Harilal
Opt. Lett. 43(17) 4065-4068 (2018)